一种新型比色荧光增强型CN-探针的合成与性能研究
收稿日期: 2018-04-17
修回日期: 2018-05-15
网络出版日期: 2018-05-24
基金资助
国家自然科学基金（Nos.21262034，21364013）、西南石油大学精细化学品青年科技创新团队（No.2017CXTD05）资助项目.
Synthesis and Properties of a Novel Colorimetric and Fluorescent Turn-On Sensor for Cyanide
Received date: 2018-04-17
Revised date: 2018-05-15
Online published: 2018-05-24
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21262034, 21364013), and the Youth Science and Technology Innovation Team of Southwest Petroleum University (No. 2017CXTD05).
设计并合成一种具有席夫碱结构的新型荧光增强型探针7-（二丁基氨基）-2'-[（2-羟基苯亚甲基）氨基]-3-甲基-1-苯基-1H-螺[色烯并[2，3-c]吡唑-4，1'-异吲哚啉]-3'-酮（SCPz-S），通过1H NMR、13C NMR及高分辨质谱（HRMS）对其结构进行了表征.利用紫外-可见光谱和荧光光谱考察探针SCPz-S的离子识别性能，研究发现探针SCPz-S在THF/H2O（V：V=1930：50，5 mmol/L Tris-HCl，pH=7.4）中对CN-具有比色和荧光上的双重响应.加入CN-后，探针SCPz-S的体系会由无色变为淡黄色，在575 nm荧光增强1060倍.探针SCPz-S拥有良好的抗干扰能力和很广的pH适用范围（pH=3~12）.探针对CN-的检出限达到1.121×10-8 mol/L，并对其识别机理进行了研究.
郝云鹏 , 解正峰 , 包万睿 , 王馨 , 石伟 . 一种新型比色荧光增强型CN-探针的合成与性能研究[J]. 有机化学, 2018 , 38(8) : 2109 -2115 . DOI: 10.6023/cjoc201804034
A novel fluorescent "turn-on" probe 7-(dibutylamino)-2'-((2-hydroxybenzylidene)amino)-3-methyl-1-phenyl-1H-spiro[chromeno[2,3-c]pyrazole-4,1'-isoindolin]-3'-one (SCPz-S) with Schiff base structure was designed and synthesized, and characterized by 1H NMR, 13C NMR and high resolution mass spectrometry (HRMS). The UV-Vis and fluorescence spectra were used to investigate the ions recognition capability of probe SCPz-S. It was excavated that the probe SCPz-S has a dual colorimetric and fluorescence response to CN- in THF/H2O (V:V=1930:50, 5 mmol/L Tris-HCl, pH=7.4). After adding CN-, the system of probe SCPz-S will change from colorless to yellow, and fluorescence enhance 1060-fold at 575 nm. The sensor SCPz-S also has good anti-interference ability and a wide pH range from 3 to 12 applicable. Its LOD for CN- is 1.121×10-8 mol/L, and the recognition mechanism has been investigated.
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