新型天麻素中间体类似物的高效合成
收稿日期: 2018-04-02
修回日期: 2018-05-15
网络出版日期: 2018-07-05
基金资助
Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170).
Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues
Received date: 2018-04-02
Revised date: 2018-05-15
Online published: 2018-07-05
Supported by
Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170).
在葡萄糖酸的催化作用下，以4-甲酰基苯基-2，3，4，6-O-四乙酰基-β-D-葡萄糖苷和1，3-二噁烷-4，6-二酮为原料，发生Knoevenagel缩合反应合成了10种新型天麻素中间体类似物.该反应具有收率高（78%~92%）、反应温和、操作简单及环境友好等优点.此外，葡萄糖酸还可重复使用.
许招会 , 李瑜钰 , 刘德永 , 肖强 . 新型天麻素中间体类似物的高效合成[J]. 有机化学, 2018 , 38(11) : 3118 -3122 . DOI: 10.6023/cjoc201804005
Ten gastrodine intermediate analogues were synthesized by the Knoevenagel reaction of 4-formylphenyl(2,3,4,6-tetra-O-acetyl)-β-D-glucoside and 1,3-dioxane-4,6-dione with gluconic acid as a catalyst. In this reaction there are many advantages with good to excellent yields (78%~92%), mild conditions, simple operations and environmental friendliness. Additionally, gluconic acid could be recycled and reused many times without lossing its efficiency.
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