SIOC English
有机化学
高级检索

有机化学 >

2018 , Vol. 38 >Issue 12: 3165 - 3175

DOI: https://doi.org/10.6023/cjoc201806043

综述与进展

内质网荧光探针研究进展

展开
  • a 五邑大学化学与环境工程学院 江门 529020;
    b 江门市大健康国际创新研究院 江门 529020;
    c Faculty of Science, King Abdulaziz University, Jeddah 999088;
    d 兰州大学药学院 兰州 730000

收稿日期: 2018-06-28

  修回日期: 2018-07-26

  网络出版日期: 2018-08-22

基金资助

广东省教育厅基金（Nos.2017KTSCX185，2017KSYS010，2016KCXTD005）、五邑大学青年团队项目（No.2016td01）、国家自然科学基金（Nos.21472077，21772071）资助项目.

收起

Recent Progress on Endoplasmic Reticulum-Targetable Fluorescence Probe

Expand
  • a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020;
    b International Healthcare Innovation Institute, Jiangmen 529000;
    c Faculty of Science, King Abdulaziz University, Jeddah 999088;
    d School of Pharmacy, Lanzhou University, Lanzhou 730000

Received date: 2018-06-28

  Revised date: 2018-07-26

  Online published: 2018-08-22

Supported by

Project supported by the Department of Education of Guangdong Province (Nos. 2017KTSCX185, 2017KSYS010, 2016KCXTD005), the Youth Team Fund of Wuyi University, and the National Natural Science Foundation of China (Nos. 21472077, 21772071).

Fold

摘要

内质网作为亚细胞器在哺乳细胞生命活动中发挥重要作用.将内质网可视化，进一步检测其活性物质、微环境及生理过程，对于疾病的诊治具有重要的指导价值.近年来，内质网靶向荧光探针的设计与合成受到了越来越多的关注.当前已报道的内质网靶向荧光探针涵盖了单纯内质网成像、金属离子、小分子物质、大分子物质、微环境等.总结并介绍了近期报道的内质网靶向荧光探针的设计与合成工作，分析了内质网荧光探针在研究细胞生理过程中的应用，并展望了内质网靶向荧光探针的发展趋势.

关键词： 内质网; 荧光; 成像; 探针; 活性小分子

本文引用格式

吕卉, 徐学涛, 黄丹颖, 吴盼盼, 盛钊君, 刘文锋, 李冬利, Njud S. Alharbi, 张焜, 王少华 . 内质网荧光探针研究进展[J]. 有机化学, 2018 , 38(12) : 3165 -3175 . DOI: 10.6023/cjoc201806043

Abstract

The endoplasmic reticulum, a subcellular organelle, plays an important role in the life activities of mammalian cells. Therefore, visualizing the endoplasmic reticulum, and further examining its active substances, microenvironments and physiological processes have important guiding value for the diagnosis and treatment of related diseases. In recent years, the design and synthesis of endoplasmic reticulum-targetable fluorescent probes have received more and more attentions. Currently, reported endoplasmic reticulum-targetable fluorescent probes mainly include simple endoplasmic reticulum imaging, metal ions, small molecule material, big molecule material, microenvironments, etc. This article summarizes and describes the design and synthesis of the reported endoplasmic reticulum-targetable fluorescent probes, analyzes the application of endoplasmic reticulum fluorescent probes in the study of cellular physiological processes, and prospects the development trend of endoplasmic reticulum-targetable fluorescent probes.

Key words： endoplasmic reticulum; fluorescence; imaging; probe; active small molecule

参考文献

[1] Vance, J. E. Traffic 2015, 16, 1.
[2] Sovolyova, N.; Healy, S.; Samali, A.; Logue, S. E. Biol. Chem. 2014, 395, 1.
[3] Zhang, H.; Hu, J. Trends Cell Biol. 2016, 26, 934.
[4] Brodsky, J. L.; Skach, W. R. Curr. Opin. Cell Biol. 2011, 23, 464.
[5] Borgese, N.; Francolini, M.; Snapp, E. Curr. Opin. Cell Biol. 2006, 18, 358.
[6] Westrate, L. M.; Lee, J. E.; Prinz, W. A.; Voeltz, G. K. Annu. Rev. Biochem. 2015, 84, 791.
[7] Li, M.; Fan, J. L.; Li, H. D.; Du, J. J.; Long, S. R.; Peng, X. J. Biomaterials 2018, 164, 98.
[8] Liu, S. Y.; Ge, G. B.; Dong, W. B.; Peng, X. J.; Liu, F. Y.; Chen, S. S.; Sun, S. G. Sens. Actuators, A 2017, 253, 1145.
[9] Li, H. D.; Yao, Q. C.; Fan, J. L.; Du, J. J.; Wang, J. Y.; Peng, X. J. Biosens. Bioelecton. 2017, 94, 536.
[10] Xu, G.; Yan, Q. L.; Lv, X. G.; Zhu, Y.; Xin, K.; Shi, B.; Wang, R. C.; Chen, J.; Gao, W.; Shi, P.; Fan, C. H.; Zhao, C. C.; Tian, H. Angew. Chem., Int. Ed. 2018, 57, 3626.
[11] Han, H. H.; Qiu, Y. J.; Shi, Y. Y.; Wen, W.; He, X. P.; Dong, L. W.; Tan, Y. X.; Long, Y. T.; Tian, H.; Wang, H. Y. Theranostics 2017, 8, 3268.
[12] Zhang, J. J.; Fu, Y. X.; Han, H. H.; Zang, Y.; Li, J.; He, X. P.; Feringa, B. L.; Tian, H. Nat. Commun. 2017, 8, 987.
[13] Wu, H. J.; Jia, J. H.; Xu, Y. F.; Qian, X. H.; Zhu, W. P. Sens. Actuator, B 2018, 265, 59.
[14] Ti, Y. Z.; Yu, L.; Tang, Y. Jin, T. X.; Yang, M.; Wang, R.; Xu, Y. F.; Zhu, W. P. Sens. Actuator, B 2018, 265, 582.
[15] Li, D. D.; Xu, Y. Q.; Zhou, N. N.; Liu, J. X.; Wang, R.; Cheng, T.; Tang, Y.; Zhu, W. P.; Xu, Y. F.; Qian, X. H. Dyes Pigm. 2017, 136, 627.
[16] Li, J.; Chen, Y. H.; Chen, T. T.; Qiang, J.; Zhang, Z. J.; Wei, T. W.; Zhang, W.; Wang, F.; Chen, X. Q. Sens. Actuator, B 2018, 268, 446.
[17] Lee, D.; Jeong, K.; Luo, X.; Kim, G.; Yang, Y. J.; Chen, X. Q.; Kim, S.; Yoon, J. J. Mater. Chem. B 2018, 6, 2541.
[18] Zhang, Z. J.; Wei, T. W.; Chen, Y. H.; Chen, T. T.; Chi, B.; Wang, F.; Chen, X. Q. Sens. Actuator, B 2018, 255, 2211.
[19] Wu, X. F.; Shi, W.; Li, X. H.; Ma, H. M. Angew. Chem., Int. Ed. 2017, 56, 15319.
[20] Xu, Y. H.; Shi, W.; He, X. Y.; Wu, X. F.; Li, X. H.; Ma, H. M. Anal. Chem. 2017, 89, 10980.
[21] Fang, Y.; Chen, W.; Shi, W.; Li, H. Y.; Xian, M.; Ma, H. M. Chem. Commun. 2017, 53, 8759.
[22] Wang, H.; Xue, K.; Li, P.; Yang, Y. Y.; He, Z. X.; Zhang, W.; Zhang, W.; Tang, B. Anal. Chem. 2018, 90, 6020.
[23] Yang, L. M.; Li, J.; Pan, W.; Wang, H. Y.; Li, N.; Tang, B. Chem. Commun. 2018, 54, 3656.
[24] Gao, X. N.; Jiang, L. L.; Hu, B.; Kong, F. P.; Liu, X. J.; Xu, K. H.; Tang, B. Anal. Chem. 2018, 90, 4719.
[25] Jones, V. C.; McKeown, L.; Verkhratsky, A.; Jones, O. T. BMC Neurosci. 2008, 9, 10.
[26] Diniz, J. R.; Correa, J. R.; Moreira, D.; Fontenele, R. S.; Oliveira, A. L.; Abdelnur, P. V.; Dutra, J. D. L.; Freire, R. O.; Rodrigues, M. O.; Neto, B. A. D. Inorg. Chem. 2013, 52, 10199.
[27] Zhang, H; Fan, J. L.; Dong, H. J.; Zhang, S. Z.; Xu, W. Y.; Wang, J. Y.; Gao, P.; Peng, X. J. J. Mater. Chem. B 2013, 1, 5450.
[28] D'Amore, C.; Orso, G.; Fusi, F.; Pagano, M. A.; Miotto, G.; Forgiarini, A.; Martin, S. D.; Castellani, G.; Ribaudo, G.; Rennison, D.; Brimble, M. A.; Hopkins, B.; Ferrarese, A.; Bova, S. Front Pharmacol. 2016, 7, 315.
[29] Collot, M.; Kreder, R.; Tatarets, A. L., Patsenker, L. D.; Mely, Y.; Klymchenko, A. Chem. Commun. 2015, 51, 17136.
[30] Kamkaew, A.; Thavornpradit, S.; Puangsamlee, T.; Xin, D.; Wanichachev, N.; Burgess, K. Org. Biomol. Chem. 2015, 13, 8271.
[31] Phaniraj, S.; Gao, Z.; Rane, D.; Peterson, B. R. Dyes Pigm. 2016, 135, 127.
[32] Zheng, S.; Huang, C.; Zhao, X.; Zhang, Y.; Liu, S.; Zhu, Q. Spectrochem. Acta A 2017, 189, 231.
[33] Meinig, J. M.; Fu, L.; Peterson, B. R. Angew. Chem., Int. Ed. 2015, 54, 9696.
[34] Lew, R. L.; Briskin, D. P.; Wyse, R. E. Plant Physiol. 1986, 82, 47.
[35] Giannini, J. L.; Gildensoph, L. H.; Reynolds-niesman, I.; Briskin, D. P. Plant Physiol. 1987, 85, 1129-1136.
[36] Lee, Y. H.; Park, N.; Park, Y. B.; Hwang, Y. J.; kang, C.; Kim, J. S. Chem. Commun. 2014, 50, 3197.
[37] Park, S. Y.; Kim, W.; Park, S. H.; Han, J. Y.; Lee, J.; Kang, C.; Lee, M. H. Chem. Commun. 2017, 53, 32.
[38] Lin, W.; Buccella, D.; Lippard, S. J. J. Am. Chem. Soc. 2013, 135, 13512.
[39] Gan, X.; Sun, P.; Li, H.; Tian, X.; Zhang, B.; Wu, J.; Tian, Y.; Zhou, H. Biosens. Bioelectron. 2016, 86, 393.
[40] Lee, M. H.; Lee, H.; Chang, M. J.; Kim, H. S.; Kang, C.; Kim, J. S. Dyes Pigm. 2016, 130, 245.
[41] Xiao, H.; Li, P.; Hu, X.; Shi, X.; Zhang, W.; Tang, B. Chem. Sci. 2016, 7, 6153.
[42] Gao, C.; Tian, Y.; Zhang, R. B.; Jing, J.; Zhang, X. Anal. Chem. 2017, 89, 12945.
[43] Xiao, H.; Liu, X.; Wu, C.; Wu, Y.; Li, P.; Guo, X.; Tang, B. Biosens. Bioelectron. 2017, 91, 449.
[44] Li, J. P.; Xia, S.; Zhang, H.; Qu, G. R.; Guo, H. M. Sens Actuator, B 2018, 255, 622.
[45] Liu, P.; Han, X. Y.; Yu, F. B.; Chen, L. X. Chin. J. Anal. Chem. 2015, 43, 1829.
[46] Ali, F.; Sreedharan, S.; Ashoka, A. H.; Saeed, H. K.; Smythe, C. G. W.; Thomas, J. A.; Das, A. Anal. Chem. 2017, 89, 12087.
[47] Tang, Y.; Ma, Y.; Xu, A.; Xu G.; Lin, W. Methods Appl. Fluoresc. 2017, 5, 024005.
[48] Tang, Y.; Xu, A.; Ma, Y.; Xu, G.; Gao, S.; Lin, W. Sci. Rep. 2017, 7, 12944.
[49] Meng, Q.; Jia, H.; Succar, P.; Zhao, L.; Zhang, R.; Duan, C.; Zhang, Z. Biosens. Bioelectron. 2015, 74, 461.
[50] Hakamata, W.; Tamura, S.; Hirano, T.; Nishio, T. ACS Med. Chem. Lett. 2014, 5, 321.
[51] Shaulov-Rotem, Y.; Merquiol, E.; Weiss-Sadan, T.; Moshel, O.; Salpeter, S.; Shabat, D.; Kaschani, F.; Kaiser, M.; Blum, G. Chem. Sci. 2016, 7, 1322.
[52] Xu, S.; Liu, H. W.; Hu, X. X.; Huan, S. Y.; Zhang, Y.; Liu, Y.; Yuan, L.; Qu, F. L.; Zhang, X. B.; Tan, W. Anal. Chem. 2017, 89, 7641.
[53] McMahon, B. K.; Pal, R.; Parker, D. Chem. Commun. 2013, 49, 5363.
[54] Ghule, N. V.; Bhosale, R. S.; Kharat, K.; Puyad, A. L.; Bhosale, S. V.; Bhosale, S. V. ChemPlusChem 2015, 80, 485.
[55] Upendar, R. G.; Anila, H. A.; Firoj, A.; Nandaraj, T.; Samit, C.; Amitava, D. Org. Lett. 2015, 17, 5532.
[56] Arai, S.; Lee, S. C.; Zhai, D.; Suzuki, M.; Chang, Y. T. Sci. Rep. 2014, 4, 6701.
[57] Yang, Z.; He, Y.; Lee, J. H.; Chae, W. S.; Ren, W. X.; Lee, J. H.; Kang, C.; Kim, J. S. Chem. Commun. 2014, 50, 11672.
[58] Lee, H.; Yang, Z.; Wi, Y.; Kim, T. W.; Verwilst, P.; Lee, Y. H.; Han, G.; Kang, C.; Kim, J. S. Bioconjugate Chem. 2015, 26, 2474.
[59] Xiao, H.; Wu, C.; Li, P.; Gao, W.; Zhang, W.; Zhang, W.; Tong, L.; Tang, B. Chem. Sci. 2017, 8, 7025.
[60] Takakura, H.; Zhang, Y.; Erdmann, R. S.; Thompson, A. D.; Lin, Y.; McNellis, B.; Rivera-Molina, F.; Uno, S.; Kamiya, M.; Urano, Y.; Rothman, J. E.; Bewersdorf, J.; Schepartz, A.; Toomre, D. Nat. Biotechnol. 2017, 35, 773.
[61] Kaplfán, P.; RaCay, P.; Lehotský, J.; Mézešová, V. Neurochem. Res. 1995, 20, 815.
[62] Yang, Z.; Wi, Y.; Yoon, Y. M.; Verwilst, P.; Jang, J. H.; Kim, T. H.; Kang, C.; Kim, J. S. Chem. Asian J. 2016, 11, 527.

Options
文章导航

/

〈 〉