钌(Ⅱ)-催化芳胺C-H键与炔丙醇的高选择性[3+2]环化反应
收稿日期: 2018-06-25
修回日期: 2018-07-23
网络出版日期: 2018-08-23
基金资助
海南省科协青年科技英才学术创新计划（Nos.QCXM201808，QCXM201707）资助项目.
Ruthenium(Ⅱ)-Catalyzed C-H Bond Regioselective[3+2] Annulation of Arylamines with Propargyl Alcohols
Received date: 2018-06-25
Revised date: 2018-07-23
Online published: 2018-08-23
Supported by
Project supported by the Program of Hainan Association for Science and Technology Plans to Youth R & D Innovation (Nos. QCXM201808, QCXM201707).
白丽丽 , 王颖 , 王烁今 , 孔杜林 , 付艳 , 彭德乾 , 文丽君 , 陈训 . 钌(Ⅱ)-催化芳胺C-H键与炔丙醇的高选择性[3+2]环化反应[J]. 有机化学, 2018 , 38(12) : 3242 -3249 . DOI: 10.6023/cjoc201806039
A simple and efficient ruthenium(Ⅱ)-catalyzed C-H bond regioselective[3+2] annulation of arylamines with propargyl alcohols has been reported. This protocol provides a facile approach to hydroxy-containing indole skeleton, which could be employed for constructing more complex and useful pharmaceutical molecules. Meantime, the kinetic isotope effect was further investigated and the results indicated that the C-H bond-breaking was possibly involved in the rate-limiting step of this transformation.
Key words： ruthenium(Ⅱ); C-H bond; regioselective; annulation reaction
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