多杀菌素A衍生物的合成及其生物活性研究
收稿日期: 2018-07-01
修回日期: 2018-08-02
网络出版日期: 2018-09-05
基金资助
国家自然科学基金（No.41471198）资助项目.
Study on the Synthesis and Insecticidal Activity of Spinosyn A Derivatives
Received date: 2018-07-01
Revised date: 2018-08-02
Online published: 2018-09-05
Supported by
Project supported by the National Natural Science Foundation of China (No. 41471198).
张凯 , 李加荣 , 温都苏 , 刘洪林 , 王海邮 , 阿拉木斯 . 多杀菌素A衍生物的合成及其生物活性研究[J]. 有机化学, 2018 , 38(12) : 3363 -3372 . DOI: 10.6023/cjoc201807001
Spinosyns are a novel kind of biopesticide produced by Saccharopolyspora spinosa. Spinosyns have been widely applied in pest control because of their broad insecticidal spectrum, high insecticidal activity, low environmental impact, and low toxicity. To identify spinosyn compounds with improved insecticidal activity, a series of D-forosamine replacement derivatives of spinosyn A were synthesized. The insecticidal activities of the synthetic derivatives were evaluated against 3rd-instar larvae of Plutella xylostella. All derivatives exhibited good insecticidal activity to P. xylostella.
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