镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(Z)-单氟烯烃
收稿日期: 2018-07-06
修回日期: 2018-09-05
网络出版日期: 2018-09-18
基金资助
国家自然科学基金（Nos.21472043，21272070）资助项目.
Stereoselective Synthesis of Z-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of gem-Difluorostyrenes with Organozinc Reagents
Received date: 2018-07-06
Revised date: 2018-09-05
Online published: 2018-09-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472043, 21272070).
张娟 , 王碧云 , 刘熠森 , 曹松 . 镍催化的偕二氟芳基乙烯与有机锌交叉偶联反应立体选择性合成(Z)-单氟烯烃[J]. 有机化学, 2019 , 39(1) : 249 -256 . DOI: 10.6023/cjoc201807013
An efficient method for the synthesis of various Z-fluorostyrene derivatives via nickel-catalyzed cross-coupling of gem-difluorostyrenes with organozinc reagents with the assistance of LiCl was developed. The reaction proceeds efficiently under mild condition, affording monofluoroalkenes in moderate to good yields. This novel method exhibits good functional group compatibility and excellent stereoselectivity.
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