N,N-二甲基甲酰胺二烷基缩醛对含N-H化合物的N-烷基化反应
收稿日期: 2018-07-04
修回日期: 2018-09-04
网络出版日期: 2018-09-26
基金资助
国家食品科学与工程一流学科建设项目（No.JUFSTR20180101）、江苏省政策引导类专项基金（No.BZ2016021）资助项目.
N-Alkylation of N-H Compounds in N,N-Dimethylformamide Dialkyl Acetal
Received date: 2018-07-04
Revised date: 2018-09-04
Online published: 2018-09-26
Supported by
Project supported by the National First-Class Discipline Program of Food Science and Technology (No. JUFSTR20180101) and the Jiangsu Province Policy Guidance Special Fund (No. BZ2016021).
以N，N-二甲基甲酰胺二烷基缩醛为烷基来源，实现了不同的含N-H化合物N-烷基化反应.通过研究溶剂、温度、反应时间、N，N-二甲基甲酰胺二烷基缩醛用量等因素对反应的影响，获得了最优的反应条件，然后考察不同N，N-二甲基甲酰胺二烷基缩醛对底物烷基化能力的影响.该反应具有原料简单易得、操作简便、反应条件温和、底物普适性较好和无金属参与等优点.
关键词： N,N-二甲基甲酰胺二烷基缩醛; 氮烷基化; 合成
赵辉 , 朱孝云 , 胡小霞 , 刘延革 , 唐春雷 , 冯柏年 . N,N-二甲基甲酰胺二烷基缩醛对含N-H化合物的N-烷基化反应[J]. 有机化学, 2019 , 39(2) : 434 -442 . DOI: 10.6023/cjoc201807010
The N,N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds. The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N,N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N,N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated.
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