钯催化N,N-二甲基甲酰胺与胺高效合成甲酰胺
收稿日期: 2018-09-15
修回日期: 2018-11-30
网络出版日期: 2018-12-07
基金资助
国家自然科学基金（Nos.21562010，21601039）资助项目.
Pd-Catalyzed N-Formylation of Amines with N,N-Dimethylformamide
Received date: 2018-09-15
Revised date: 2018-11-30
Online published: 2018-12-07
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21562010,21601039).
报道了一种醋酸钯催化N，N-二甲基甲酰胺（DMF）与各类胺高效合成甲酰胺化合物的方法.该反应体系简单，具有催化效率高，不需要其它溶剂及共催化剂，底物普适范围广的优点，为合成甲酰胺化合物提供了一种快速，实用的方法.
关键词： 醋酸钯; N,N-二甲基甲酰胺(DMF); 胺; N-甲酰化
李春 , 王梦娜 , 陆逊花 , 杨元勇 , 张林 . 钯催化N,N-二甲基甲酰胺与胺高效合成甲酰胺[J]. 有机化学, 2019 , 39(4) : 1109 -1115 . DOI: 10.6023/cjoc201809020
A highly efficient protocol for the transamidation of N,N-dimethylformamide (DMF) and amines has been developed, utilizing a catalytic amount Pd(OAc)2. This methodology has a broad substrate scope for aliphatic, aromatic, and heterocyclic amines. And this process is simple and easily performed without solvent and co-catalyst.
Key words： Pd(OAc)2; N,N-dimethylformamide (DMF); amines; N-formylation
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