一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物
收稿日期: 2018-12-05
修回日期: 2018-12-29
网络出版日期: 2019-01-18
基金资助
国家自然科学基金（Nos.21462015，31760093）、海南省自然科学基金（No.218MS045）、教育部创新团队发展计划（No.IRT-16R19）资助项目.
Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126
Received date: 2018-12-05
Revised date: 2018-12-29
Online published: 2019-01-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21462015, 31760093), the National Natural Science Foundation of Hainan Province (No. 218MS045), the Program for Innovative Research Team in University (No. IRT-16R19).
综合运用多种现代色谱学分离方法对红树来源真菌Penicillium citrinum HL-5126中的次级代谢产物进行了研究，从中分离获得2个新的异香豆素类化合物，通过1D NMR，2D NMR和HR-ESI-MS等波谱鉴定技术确定结构分别为penicimarin J（1）和penicimarin K（2）.通过测定圆二色谱并与文献数据对照，确定了化合物1和2的绝对构型.化合物1和2对α-Glucosidase显示一定的抑制活性，IC50值分别为18.37和25.86μg/mL.
梅荣清 , 黄国雷 , 王斌 , 白猛 , 罗由萍 , 陈光英 , 郑彩娟 . 一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物[J]. 有机化学, 2019 , 39(5) : 1479 -1482 . DOI: 10.6023/cjoc201812008
Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC50 values of 18.37 and 25.86 μg/mL, respectively.
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