白芍中一种内生真菌Penicillium mariae-crucis的次生代谢产物研究
收稿日期: 2018-11-21
修回日期: 2019-01-04
网络出版日期: 2019-01-31
基金资助
安徽省中央引导地方科技发展专项（No.2017070702D173）、安徽中医药大学校级探索性科研项目（Nos.2017HXTS31，2017HXTS2）和植物化学与西部植物资源持续利用国家重点实验室（No.P2017-KF03）资助项目.
Secondary Metabolites of Endophytic Fungus Penicillium mariae-crucis from Paeonia lactiflora Pall
Received date: 2018-11-21
Revised date: 2019-01-04
Online published: 2019-01-31
Supported by
Project supported by the Special Guide for Local Science and Technology Development Guided by the Central Committee of Anhui Province (No.2017070702D173),the Anhui University of Chinese Medicine (Nos.2017HXTS31,2017HXTS2) and the State Key Laboratory of Phytochemistry and Plant Resources in West China (No.P2017-KF03).
综合运用多种现代色谱学分离方法对白芍中内生真菌Penicillium mariae-crucis的次生代谢产物进行了研究，从其发酵液的乙酸乙酯萃取部位中分离得到了10个化合物，采用多种现代波谱技术确定了这些化合物的化学结构，分别鉴定为：penicmariae-crucis A （1）、penicmariae-crucis B （2）、penicmariae-crucis C （3）、penicmariae-crucis D （4）、（E）-2-甲基己-3-烯二酸（5）、2-乙酰基-3-羟基-5-甲氧基苯乙酸（6）、2-乙酰基-3-羟基-5-甲氧基苯乙酸甲酯（7）、2-乙酰基-3，5-二羟基苯乙酸甲酯（8）、β-谷甾醇（9）、过氧化麦角甾醇（10）·其中化合物1~4为新化合物，化合物5为新天然产物，所有化合物均为首次从内生真菌P. mariae-crucis中分离得到.
关键词： 白芍; P. mariae-crucis; 内生真菌; 化学成分
王举涛 , 马宗慧 , 王国凯 , 许凤清 , 郁阳 , 王刚 , 刘劲松 . 白芍中一种内生真菌Penicillium mariae-crucis的次生代谢产物研究[J]. 有机化学, 2019 , 39(4) : 1136 -1141 . DOI: 10.6023/cjoc201811026
Four new compounds, penicmariae-crucis A (1), penicmariae-crucis B (2), penicmariae-crucis C (3), penicmariae-crucis D (4), and a new natural product, (E)-2-methylhex-3-enedioic acid (5), together with five known compounds, O-methylcurvulinic acid (6), methyl 2-acetyl-3-hydroxy-5-methoxyphenylacetate (7), methyl 2-acetyl-3,5-dihydroxyphenyl-acetate (8), β-sitosterol (9) and ergosterol peroxide (10), were isolated from the ethyl acetate extract of endophytic fungus Penicillium mariae-crucis in Paeonia lactiflora Pall. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from P. mariae-crucis for the first time.
[1] Zhang, L.; Zhao, B. J.; Yuan, J. R.; Wang, C. F.; Feng, L.; Jia, X. B. China J. Chin. Mater. Med. 2016, 41, 1835(in Chinese).(章丽, 赵冰洁, 袁嘉瑞, 汪春飞, 封亮, 贾晓斌, 中国中药杂志, 2016, 41, 1835.)
[2] Shi, Y. M.S. Thesis, Shaanxi University of Science and Technology, Xi'an, 2015 (in Chinese).(石钰, 硕士论文, 陕西科技大学, 西安, 2015.)
[3] Wang, H. H.; Li, G.; Peng, X. P.; Lou, H. X. Acta Pharm. Sin. 2018, 53, 1(in Chinese).(王航航, 李刚, 彭晓娉, 娄红祥, 药学学报, 2018, 53, 1.)
[4] Chen, X. D. Microbiology (Beijing, China) 2012, 39, 282(in Chinese).(陈向东, 微生物学通报, 2012, 39, 282.)
[5] Hou, X. Q.; Guo, S. X. China J. Chin. Mater. Med. 2014, 39, 3232(in Chinese).(侯晓强, 郭顺星, 中国中药杂志, 2014, 39, 3232.)
[6] Liang, Y. M.; Yu, Y.; Sun, Y. P.; Liu, J. S.; Ma, Z. H.; Liu, H. T.; Wang, G. Nat. Prod. Res. Dev. 2018, 30, 783(in Chinese).(梁益敏, 郁阳, 孙云鹏, 刘劲松, 马宗慧, 刘海涛, 王刚, 天然产物研究与开发, 2018, 30, 783.)
[7] Cheng, X. Z.; Xu, Y.; Ge, Y. B.; Wei, L.; Yan, A. L.; Zhang, Y.; Liu, X. L.; Xu, J.; Guo, H. J. Anhui Agric. Sci. 2016, 44, 162(in Chinese).(程孝中, 许勇, 葛永斌, 魏磊, 燕傲蕾, 张宇, 刘西岭, 徐娟, 郭慧, 安徽农业科学, 2016, 44, 162.)
[8] Shaala, L. A.; Youssef, D. T. Mar. Drugs 2015, 13, 1698.
[9] Chou, T. H.; Chen, I. S.; Hwang, T. L.; Wang, T. Ch.; Lee, T. H.; Cheng, L. Y.; Chang, Y. C.; Cho, J. Y.; Chen, J. J. J. Nat. Prod. 2008, 71, 1692.
[10] Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107.
/
| 〈 |
|
〉 |
