锌-脯氨酸复合物催化的水相Knoevenagel缩合
收稿日期: 2018-12-26
修回日期: 2019-01-16
网络出版日期: 2019-01-31
基金资助
国家自然科学基金（No.81573340）及山东省自主创新及成果转化专项（No.2015ZDXX0302A02）资助项目.
Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water
Received date: 2018-12-26
Revised date: 2019-01-16
Online published: 2019-01-31
Supported by
Project supported by the National Natural Science Foundation of China (No. 81573340) and the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02).
报道了锌-脯氨酸复合物催化下的水相Knoevenagel缩合反应.17种芳香醛以及2种脂肪环酮与丙二腈在80℃下反应5～10 min，能够以84%～99%的收率得到相应的Knoevenagel缩合产物.催化剂回收重复使用10次，其催化活性不受影响.
关键词： Knoevenagel缩合; 水相反应; 锌-脯氨酸复合物; 环境友好
颜世强 , 郭伟 , 王文笙 , 张伟 . 锌-脯氨酸复合物催化的水相Knoevenagel缩合[J]. 有机化学, 2019 , 39(5) : 1469 -1474 . DOI: 10.6023/cjoc201812046
Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.
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