(±)-Parvistemonine A的全合成
收稿日期: 2019-01-07
修回日期: 2019-02-12
网络出版日期: 2019-03-08
基金资助
山西省回国留学人员科研资助基金（No.2015-020）和山西省高等学校科技创新基金（No.2016115）资助项目.
Total Synthesis of Racemic (±)-Parvistemonine A
Received date: 2019-01-07
Revised date: 2019-02-12
Online published: 2019-03-08
Supported by
Project supported by the Shanxi Scholarship Council of China (No. 2015-020) and the Science and Technology Innovation Project of Shanxi Province (No. 2016115).
Parvistemonine A为从对叶百部中分离得的百部生物碱.以化合物7为原料，通过路易斯酸催化的傅克及内酯化的串联反应，Vilsmeier-Haack及Julia-Kocienski烯烃化等6步反应首次完成了百部生物碱（±）-parvistemonine A的全合成工作，为parvistemonine A衍生物的合成和及其生物活性研究打下基础.
关键词： 天然产物; 百部生物碱; parvistemonine A; 化学合成
马开庆 , 任虎斌 , 吴晓晓 , 钞建斌 , 秦雪梅 . (±)-Parvistemonine A的全合成[J]. 有机化学, 2019 , 39(7) : 2094 -2098 . DOI: 10.6023/cjoc201901010
Parvistemonine A was isolated from Stemona parviflora. The total synthesis of racemic parvistemonine A was completed in 6 steps for the first time, employing compound 7 as the starting material. The synthetic strategy features a tandem Friedel-Crafts cyclization and lactonization, Vilsmeier-Haack and Julia-Kocienski olefination. This study laid the foundation for the synthesis of the parvistemonine A derivative and its biological activity research.
Key words： natural product; stemona alkaloids; parvistemonine A; chemical synthesis
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