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2019 , Vol. 39 >Issue 6: 1568 - 1582

DOI: https://doi.org/10.6023/cjoc201903044

综述与进展

不对称氢甲酰化反应研究进展

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  • a 武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室 武汉 430072;
    b 武汉大学化学与分子科学学院 有机硅化合物及材料教育部工程中心 武汉 430072;
    c 南方科技大学化学系 深圳格拉布斯研究院 深圳 518055;
    d 武汉大学 索维奇分子科学研究中心 武汉 430072

收稿日期: 2019-03-22

  修回日期: 2019-04-23

  网络出版日期: 2019-05-06

基金资助

国家自然科学基金（No.21871212）和湖北省自然科学基金（No.2018CFB430）资助项目.

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Recent Advances in Asymmetric Hydroformylation

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  • a Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
    b Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072;
    c Department of Chemistry, Southern University of Science and Technology, Shenzhen Grubbs Institute, Shenzhen 518055;
    d Sauvage Center for Molecular Sciences, Wuhan University, Wuhan 430072

Received date: 2019-03-22

  Revised date: 2019-04-23

  Online published: 2019-05-06

Supported by

Project supported by the National Natural Science Foundation of China (No. 21871212) and the Natural Science Foundation of Hubei Province (No. 2018CFB430).

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摘要

烯烃的不对称氢甲酰化反应是合成手性醛的重要方法之一.近年来，不对称氢甲酰化反应研究取得了重要进展，发展了一系列适用于不对称氢甲酰化的新配体，实现了几类重要烯烃的不对称氢甲酰化反应，为手性醛的合成提供了简单高效的方法.介绍了不对称氢甲酰化研究的新进展，重点对几类代表性底物的不对称氢甲酰化反应以及相关配体进行了总结.

关键词： 烯烃; 不对称氢甲酰化; 醛; 手性膦配体; 铑

本文引用格式

李帅龙, 李庄星, 由才, 吕辉, 张绪穆 . 不对称氢甲酰化反应研究进展[J]. 有机化学, 2019 , 39(6) : 1568 -1582 . DOI: 10.6023/cjoc201903044

Abstract

Asymmetric hydroformylation is one of the most important reactions for preparation of chiral aldehydes from alkenes. Recently, significant progress has been made in this field and a series of new ligands have been developed. Asymmetric hydroformylation of several important alkenes has been achieved, offering efficient and concise methods for the synthesis of chiral aldehydes. In this review, the achievements of asymmetric hydroformylation of typical alkenes and the development of ligands for asymmetric hydroformylation are summarized.

Key words： alkene; asymmetric hydroformylation; aldehyde; chiral phosphine ligand; rhodium

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