通过锌催化区域选择性氧化反应实现3-烯-1-炔的1,4-官能团化
收稿日期: 2019-03-25
修回日期: 2019-04-24
网络出版日期: 2019-05-06
基金资助
浙江省公益技术应用研究计划（No.LGG19B040001）、台州市科技计划（No.1801gy21）、国家自然科学基金（Nos.21572186，21622204）和教育部创新团队资助项目.
1,4-Functionalization of 3-En-1-ynes with Alcohols via Zinc-Catalyzed Regioselective N-Oxide Oxidation
Received date: 2019-03-25
Revised date: 2019-04-24
Online published: 2019-05-06
Supported by
Project supported by the Zhejiang Provincal Public Welfare Technology Research Program (No. LGG19B040001), the Taizhou Science and Technology Project (No. 1801gy21), the National Natural Science Foundation of China (Nos. 21572186, 21622204) and the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).
郑人华 , 郭海昌 , 阳明洋 , 刘梦琪 , 叶龙武 . 通过锌催化区域选择性氧化反应实现3-烯-1-炔的1,4-官能团化[J]. 有机化学, 2019 , 39(6) : 1672 -1680 . DOI: 10.6023/cjoc201903054
γ-Hydroxyl or γ-alkoxyl-substituted α,β-unsaturated carbonyls widely exist in a variety of natural products and bioactive molecules. Herein, the realization of 1,4-functionalization of 3-en-1-ynes with alcohols through zinc-catalyzed regioselective N-oxide oxidation is described. This tandem reaction allows the practical synthesis of a range of valuable γ-alkoxyl-substituted-α,β-unsaturated amides in moderate to good yields.
Key words： oxidation; 1,4-functionalization; alkynes; tandem reaction
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