三丁基膦催化的查尔酮与丙烯酸酯的交叉Rauhut-Currier反应
收稿日期: 2019-04-08
修回日期: 2019-05-04
网络出版日期: 2019-05-15
基金资助
国家自然科学基金（Nos.21672109，21871148，21472097）和天津市自然科学基金（No.15JCYBJC20000）资助项目.
Tributylphosphine Catalyzed Cross Rauhut-Currier Reaction of Chalcones and Acrylates
Received date: 2019-04-08
Revised date: 2019-05-04
Online published: 2019-05-15
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21672109, 21871148, 21472097) and the Natural Science Foundation of Tianjin City (No. 15JCYBJC20000).
Rauhut-Currier反应是一种高效构筑碳碳键的原子经济性的方法，但较差的选择性一直限制了该反应的应用，经过条件筛选，以三丁基膦为催化剂，成功实现了查尔酮与丙烯酸酯之间的交叉Rauhut-Currier反应，可以有效合成多官能团化丙烯酸酯类化合物.
关键词： 三丁基膦; 催化; Rauhut-Currier反应; 查尔酮; 丙烯酸酯
谷迎春 , 黄有 . 三丁基膦催化的查尔酮与丙烯酸酯的交叉Rauhut-Currier反应[J]. 有机化学, 2019 , 39(8) : 2251 -2256 . DOI: 10.6023/cjoc201904017
Rauhut-Currier (RC) reaction is an effective atom-economic method to construct C-C bond. However, the application of this reaction is limited by the lack of selectivity. Herein, an efficient intermolecular cross Rauhut-Currier reaction between chalcones and acrylates in the presence of the tributylphosphine catalyst was developed, the reactions were carried out in mild conditions, and performed well with a series of substrates, delivering the desired products with acceptable to good yields.
Key words： tributylphosphine; catalysis; Rauhut-Currier reaction; chalcone; acrylate
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