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2019 , Vol. 39 >Issue 10: 2786 - 2795

DOI: https://doi.org/10.6023/cjoc201903060

综述与进展

用于人血清白蛋白检测的有机荧光分子探针的研究进展

  • 吕陶玉赜 ,
  • 朱康宁 ,
  • 刘斌
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  • 深圳大学材料学院 深圳 518060

收稿日期: 2019-03-27

  修回日期: 2019-04-26

  网络出版日期: 2019-05-21

基金资助

国家自然科学基金资助项目(21602139)

收起

Recent Advances of Organic Fluorescent Probes for Detection of Human Serum Albumin

  • Taoyuze Lü ,
  • Kangning Zhu ,
  • Bin Liu
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  • College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060

Received date: 2019-03-27

  Revised date: 2019-04-26

  Online published: 2019-05-21

Supported by

Project supported by the National Natural Science Foundation of China(21602139)

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摘要

人血清白蛋白作为血浆中最丰富的一种蛋白质, 在生理过程中有着重要的作用, 例如维持血液渗透压、运载小分子配体等. 白蛋白在生物样本中的含量能够反映出样本的健康状况, 因此标定白蛋白含量在临床疾病诊断中有着很大的用途. 随着荧光探针技术的发展, 近几年特异性检测血清白蛋白的荧光探针涌现而出. 总结了近年来出现的有机荧光分子探针, 根据探针的结构、作用机理、光谱特征、检测极限以及探针与白蛋白的结合位点等进行了简要的分类, 并由此分析了针对人血清白蛋白的荧光探针的发展趋势与前景.

关键词： 人血清白蛋白; 荧光探针; 结合位点; 检测机理

本文引用格式

吕陶玉赜 , 朱康宁 , 刘斌 . 用于人血清白蛋白检测的有机荧光分子探针的研究进展[J]. 有机化学, 2019 , 39(10) : 2786 -2795 . DOI: 10.6023/cjoc201903060

Abstract

Human serum albumin (HSA) is the most abundant protein in human blood plasma, which plays important roles in physiological and biological processes, such as keeping the osmotic pressure and transporting small molecular ligands. The level of HSA in in biological samples especially in blood serum can reveal several health conditions, and thus, quantitative determination of HSA has vital importance for disease diagnosis. In recent years, as the rapid development of fluorescent probe technique, a great number of fluorescent probes have been reported for sensitive and selective detection of HSA. This article summarizes recent reported organic-based fluorescent probes, subsequently carefully describes the chemical structures, sensing mechanisms, spectral features, limit of detection, and binding sites, and moreover, the future developments and prospects for HSA detection by using fluorescent probes have been discussed

Key words： human serum albumin; fluorescent probes; binding sites; sensing mechanism

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