两亲聚肽/螺烯的电荷复合自组装行为研究
收稿日期: 2019-04-15
修回日期: 2019-05-07
网络出版日期: 2019-05-21
基金资助
国家自然科学基金(No. 51573088)
Study of Charge-Conjugated Self-Assembly Behavior of Amphiphilic Block Copolypeptides/Helicene
Received date: 2019-04-15
Revised date: 2019-05-07
Online published: 2019-05-21
Supported by
Project supported by the National Natural Science Foundation of China(No. 51573088)
研究了包含聚肽嵌段的两亲共聚物聚乙二醇-b-聚(L-谷氨酸)(PEG-b-PGlu)与4-甲基-4-氮杂[4]螺烯鎓离子(Me[4]H)的电荷复合自组装行为, 讨论了聚肽链段长度、谷氨酸单元与螺烯物质的量比、pH值等因素对组装体形貌的影响. 研究发现, 当刚-柔型嵌段聚合物与刚性、大尺寸并具有诱导作用的小分子共同组装时, 遵循与柔性大分子电荷复合组装完全不同的规律. PEG-b-PGlu/Me[4]H的电荷复合组装体形貌由π-π堆叠作用、两亲嵌段聚肽的亲疏水比、PGlu链段的刚硬程度共同决定, 这些作用在组装过程中相互制约, 当π-π堆叠作用占主导地位时, 得到以指针状和条带状等平面结构为主的组装形貌.
王婧琳 , 沈程硕 , 唐颂超 , 姚远 . 两亲聚肽/螺烯的电荷复合自组装行为研究[J]. 有机化学, 2019 , 39(10) : 2973 -2979 . DOI: 10.6023/cjoc201904038
Amphiphilic block copolypeptides of polyethylene glycol-b-poly(L-glutamic acid) (PEG-b-PGlu) were synthesized to self-assemble with 4-methyl-4-aza[4]helicene onium ion (Me[4]H) in water through charge-conjugation. The morphology of the assemblies was studied by varying PGlu block length, the molar ratio of Glu unit/Me[4]H and pH value. It was found that when rigid-flexible block copolymers were assembled together with small molecules which had rigid, large size and inductive effect, they would follow a completely different law from the charge-conjugated assembly of flexible macromolecules. The self-assemblies were controlled by the π-π stacking of helicene, together with the volume fraction of the hydrophobic parts and the rigidity of PGlu segments. These effects restricted each other in the assembly process. When π-π stacking was dominant, assembly morphologies with pointer-like and strip-like planar structures were obtained.
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