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2019 , Vol. 39 >Issue 10: 2705 - 2712

DOI: https://doi.org/10.6023/cjoc201904014

综述与进展

基于未活化烯烃自由基加成/环化反应合成二氢吲哚类化合物的研究进展

  • 刘颖杰 ,
  • 林立青 ,
  • 韩莹徽 ,
  • 张鑫
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  • a 哈尔滨商业大学药学院 哈尔滨 150076
    b 哈尔滨医科大学附属第一医院泌尿外科 哈尔滨 150001

收稿日期: 2019-04-06

  修回日期: 2019-05-27

  网络出版日期: 2019-06-12

基金资助

黑龙江省创新人才资助项目(UNPYSCT-2016181)

收起

Recent Advances of the Synthesis of Indolines by Unactivated Alkenes

  • Yingjie Liu ,
  • Liqing Lin ,
  • Yinghui Han ,
  • Xin Zhang
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  • a School of Pharmacy, Harbin University of Commerce, Harbin 150076
    b Department of Urology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001

Received date: 2019-04-06

  Revised date: 2019-05-27

  Online published: 2019-06-12

Supported by

Project supported by the Program of Young Innovators of Education Department of Heilongjiang Province(UNPYSCT-2016181)

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摘要

二氢吲哚是一类具有广泛生物学特性的重要杂环, 是许多天然产物和生物活性化合物的关键结构骨架. 有效的二氢吲哚合成方法已成为广泛研究的主题. 描述了利用未活化烯烃合成各种官能化二氢吲哚的最新研究, 其涉及在氧化剂存在下的自由基加成/环化反应, 这些反应通常用容易获得的氧化剂和不同的金属或非金属作为催化剂, 在中性条件下进行反应.

关键词： 二氢吲哚; 烯烃; 氧化剂; 官能团; 自由基

本文引用格式

刘颖杰 , 林立青 , 韩莹徽 , 张鑫 . 基于未活化烯烃自由基加成/环化反应合成二氢吲哚类化合物的研究进展[J]. 有机化学, 2019 , 39(10) : 2705 -2712 . DOI: 10.6023/cjoc201904014

Abstract

Indolines, an important class of heterocycles with a wide range of biological properties, are a key structural motif in numerous natural products and biologically active compounds. As a result, efficient methods for indolines synthesis have been the subject of extensive studies. In this review, recent studies on the synthesis of various functionalized indolines using unactivated alkenes are described. It involves radical addition/cyclization reaction in the presence of oxidizing agent, which is usually carried out under neutral reaction conditions using readily available oxidizing agents and different transition metals or under metal-free as catalysts.

Key words： indolines; alkenes; oxidizing agent; functional group; free radical

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