碱性磷酸酶荧光探针的研究进展
收稿日期: 2019-03-04
网络出版日期: 2019-06-19
基金资助
陕西省科技厅重点(2018PT-31);安康市主导产业重大科研攻关(2016AKZDCY002);安康学院博士启动基金(2018AYQDZR06);农业部富硒产品开发国家地方联合工程实验室开放课题(Se-2018B02);陕西省大学生创新创业训练计划(201839032)
Research Progress in the Fluorescent Probes for Alkaline Phosphatase
Received date: 2019-03-04
Online published: 2019-06-19
Supported by
the Key Projects of Shaanxi Provincial Science & Technology Department(2018PT-31);the Major Scientific Research Projects of the Leading Industry of Ankang City(2016AKZDCY002);the Doctor's Initial Funding of Ankang University(2018AYQDZR06);the Key Laboratory of Se-Enriched Products Development and Quality Control, Ministry of Agriculture(Se-2018B02);the Shaanxi Provincial Innovation Experiment Program for University Students(201839032)
碱性磷酸酶（ALP）是一种广泛存在于各种哺乳动物组织中的重要酶，作为生物标记物和诊断指标为分子生物学的研究应用及人类疾病治疗提供了重要信息.由于其在人类身体健康方面的信息可靠性，近年来在荧光检测技术的研究日趋激烈，已发展成为一类重要的检测方法.根据不同的发光特点从（1）基于激发态分子内质子转移（ESIPT）和分子内电荷转移型（ICT）的传感体系、（2）基于聚集诱导发光的传感体系（AIE）、（3）基于降低给电子能力（D d-E）或扰乱共轭π电子的传感体系（D π-C）和（4）基于荧光内滤效应（IFE）的传感体系几个方面综述了近年来ALP的荧光检测、活性评价及生物成像方面的研究进展，并对其发展趋势做了展望.
张继东 , 刘鸿泽 , 孟丽 . 碱性磷酸酶荧光探针的研究进展[J]. 有机化学, 2019 , 39(11) : 3132 -3144 . DOI: 10.6023/cjoc201903008
Alkaline phosphatase (ALP) is an important enzyme for various mammalian tissues. As a biomarker and diagnostic indicator, ALP provides important information for the applied research of molecular biology and the treatment of human diseases. Due to its reliability of information in human health, the research on fluorescence detection as important detection method has become intense in recent years. The fluorescent chemosensors are categorized by different luminous feature involving excitedstate intramolecular proton transfer (ESIPT) and intramolecular charge transfer (ICT) chemosensors, aggregation-induced luminescent molecules (AIE), diminishes the electron donating ability (D d-E) and disruption of the π conjugated systems (D π-C), inner filter e?ect (IFE) chemosensors, and other sensing systems. In the end, the development tendency of the sensing ensembles for ALP is prospected.
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