天然产物Cyanolide A和Cocosolide的合成研究进展
收稿日期: 2019-04-29
网络出版日期: 2019-07-09
基金资助
国家自然科学青年基金(21302129);浙江省自然科学基金(LQ13B020002)
Synthetic Studies toward Natural Occurred Cyanolide A and Cocosolide
Received date: 2019-04-29
Online published: 2019-07-09
Supported by
the National Natural Science Foundation of China(21302129);the Natural Science Foundation of Zhejiang Province(LQ13B020002)
Cyanolide A和cocosolide是两个结构高度相似的具有对称结构的十六元内酯天然产物.Cyanolide A是从巴布亚新几内亚的Lyngbya bouillonii提取物中分离得到，具有良好的灭螺效果，可以有效阻断血吸虫病的传播，而cocosolide则是从关岛附近的金黄色的蓝藻提取物中分离.它们新颖的结构和良好的生理活性引起众多化学家的关注.根据氧杂迈克尔加成反应、氧鎓离子环化反应和过渡金属催化环化反应等四氢吡喃环构筑方法，综述了cyanolide A和cocosolide的合成工作.
关键词： Cyanolide A; Cocosolide; 全合成; 氧杂迈克尔加成; 氧鎓离子环化反应; 过渡金属催化的环化反应
张榴 , 张梦帆 , 齐陈泽 , 杨震 . 天然产物Cyanolide A和Cocosolide的合成研究进展[J]. 有机化学, 2019 , 39(11) : 3105 -3113 . DOI: 10.6023/cjoc201904071
Cyanolide A and cocosolide, two 16-membered dimeric macrolide xylopyranosides, were isolated from Guam and Papua New Guinea, respectively. Their fascinating structures and outstanding biological activities had attracted great attentions from chemists. The synthesis of cyanolide A and cocosolide is reviewed based on the construction methods of tetrahydropyran ring, which involves oxo-Michael addition reaction, oxo-carbenium cyclization and transition-metal catalyzed cyclization reactions.
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