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2019 , Vol. 39 >Issue 11: 3051 - 3064

DOI: https://doi.org/10.6023/cjoc201905024

综述与进展

基于有机小分子的三磷酸腺苷荧光传感器研究进展

  • 张继东 ,
  • 张俊 ,
  • 严瞻 ,
  • 谢娟平
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  • a 安康学院化学化工学院 陕西省富硒食品质量监督检验中心 陕西安康 725000
    b 西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室 西安 710127
    c 安康学院医学院 陕西安康 725000

收稿日期: 2019-05-12

  网络出版日期: 2019-07-17

基金资助

陕西省科技厅青年基金(2019JQ-504);安康市主导产业重大科研攻关(2016AKZDCY002);安康学院博士启动基金(2018AYQDZR06);农业部富硒产品开发国家地方联合工程实验室开放课题(Se-2018B02);陕西省大学生创新创业训练计划(201839032)

收起

Recent Progress in Fluorescent Probes for Adenosine Triphosphate Based on Small Organic Molecules

  • Jidong Zhang ,
  • Jun Zhang ,
  • Zhan Yan ,
  • Juanping Xie
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  • a Quality Supervision and Inspection Centre of Se-enriched Food of Shaanxi Province, School of Chemistry & Chemical Engineering, Ankang Univerisity, Ankang, Shaanxi 725000
    b Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127
    c School of Medicine, Ankang Univerisity, Ankang, Shaanxi 725000

Received date: 2019-05-12

  Online published: 2019-07-17

Supported by

the Youth Foundation of Shaanxi Provincial Science & Technology Department(2019JQ-504);the Major Scientific Research Projects of the Leading Industry of Ankang City(2016AKZDCY002);the Doctor's Initial Funding of Ankang University(2018AYQDZR06);the Key Laboratory of Se-enriched Products Development and Quality Control, Ministry of Agriculture(Se-2018B02);the Shaanxi Provincial Innovation Experiment Program for University Students(201839032)

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摘要

三磷酸腺苷（ATP）是各种活细胞内普遍存在的一种高能磷酸化合物，在能量的储存，细胞呼吸作用和酶催化反应等生物活动过程中扮演着重要作用.因此，对于ATP在生物体内的研究至关重要.荧光检测技术具有操作方便、选择性好和灵敏度高等优点，设计合成高效的ATP荧光传感器是近年来生物化学和分析化学领域的研究热点.根据ATP荧光传感器的结构特点和识别原理，将ATP荧光传感器分为金属Zn（Ⅱ）作为键合位点型识别，其它金属离子作为键合位点型识别和静电或氢键作用型识别.基于有机小分子荧光传感器，综述了近年来国内外ATP荧光传感器在分子设计与应用方面的研究进展，并展望了其发展趋势.

关键词： 荧光传感器; 三磷酸腺苷; 生物成像; 有机小分子

本文引用格式

张继东 , 张俊 , 严瞻 , 谢娟平 . 基于有机小分子的三磷酸腺苷荧光传感器研究进展[J]. 有机化学, 2019 , 39(11) : 3051 -3064 . DOI: 10.6023/cjoc201905024

Abstract

Adenosine triphosphate (ATP) is a high-energy phosphate compound commonly existing in various living cells, which plays important roles in the biological activities such as energy storage, cell respiration and enzyme catalytic reactions. Therefore, it is very crucial to ATP research in bio-organism. Fluorescence detection techniques has the advantages of convenient operation, good selectivity and high sensitivity, etc. In recent years, the design and synthesis of efficient ATP fluorescence sensors have become a research focus in the fields of biochemistry and analytical chemistry. According to the structure characteristics, ATP fluorescence chemosensors are categorized as Zn(Ⅱ) metal ions as recognition of bonding site type, other metal ions as recognition of bonding site type and electrostatic or hydrogen bond as interaction type. Based on organic small molecule fluorescence sensors, the recent progress in research of ATP fluorescence sensors in molecular design and application is reviewed, and the prospects for their development are discussed.

Key words： fluorescent chemosensor; adenosine triphosphate; biological imaging; small organic molecules

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