SIOC English
有机化学
高级检索

有机化学 >

2019 , Vol. 39 >Issue 11: 3264 - 3268

DOI: https://doi.org/10.6023/cjoc201905010

研究简报

拟热带灵芝中杂萜类化学成分及其蛋白酪氨酸磷酸酶1B抑制活性

  • 郭教岑 ,
  • 马青云 ,
  • 孔凡栋 ,
  • 谢晴宜 ,
  • 周丽曼 ,
  • 丁琼 ,
  • 吴友根 ,
  • 赵友兴
展开
  • a海南大学园艺学院 海口 570228
    b 中国热带农业科学院热带生物技术研究所 海南省黎药资源天然产物研究与利用重点实验室 海口 571101

收稿日期: 2019-05-07

  网络出版日期: 2019-07-24

基金资助

海南省自然科学基金(219MS078);海南省自然科学基金(2019CXTD411);现代农业产业技术体系建设专项(CARS-21);中国热带农业科学院基本科研业务(17CXTD-15);中国热带农业科学院基本科研业务(1630052016008)

收起

Meroterpenoids from the Fruiting Bodies of Ganoderma ahmadii Steyaret and Their Protein Tyrosine Phosphatase 1B Inhibitory Activities

  • Jiaocen Guo ,
  • Qingyun Ma ,
  • Fangdong Kong ,
  • Qingyi Xie ,
  • Liman Zhou ,
  • Qiong Ding ,
  • Yougen Wu ,
  • Youxing Zhao
Expand
  • a College of Horticulture, Hainan University, Haikou 570228
    b Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101

Received date: 2019-05-07

  Online published: 2019-07-24

Supported by

the Natural Science Foundation of Hainan Province(219MS078);the Natural Science Foundation of Hainan Province(2019CXTD411);the China Agriculture Research System(CARS-21);the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(17CXTD-15);the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630052016008)

Fold

摘要

利用硅胶柱层析和半制备高效液相色谱（HPLC）等色谱分离技术对拟热带灵芝的化学成分进行分离纯化，从中分离得到了3个新的酚酸杂萜类化合物（ganoduriporols C~E）.运用NMR和HRESIMS等多种波谱技术鉴定了它们的结构.对所分离的化合物进行体外PTP1B抑制活性测试，结果显示所得化合物具有明显的蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性，其IC50值分别为19.1，17.8和29.6 μmol·L-1.

关键词： 拟热带灵芝; 杂萜成分; PTP1B抑制活性

本文引用格式

郭教岑 , 马青云 , 孔凡栋 , 谢晴宜 , 周丽曼 , 丁琼 , 吴友根 , 赵友兴 . 拟热带灵芝中杂萜类化学成分及其蛋白酪氨酸磷酸酶1B抑制活性[J]. 有机化学, 2019 , 39(11) : 3264 -3268 . DOI: 10.6023/cjoc201905010

Abstract

Three new meroterpenoids of ganoduriporols C~E were isolated from the fruiting bodies of Ganoderma ahmadii Steyaret by silica gel column, high performance liquid chromatography (HPLC) and other chromatography methods. Their structures were determined by spectroscopic techniques including NMR and HR-ESI-MS. Their inhibitory activities for protein tyrosine phosphatase 1B (PTP1B) in vitro were tested. The results showed that the three compounds had obvious PTP1B inhibitory activitiy with the IC50 values of 19.1, 17.81, and 29.6 μmol·L-1, respectively.

Key words： Ganoderma ahmadii Steyaret; meroterpenoid compound; PTP1B inhibitory effect

参考文献

[1] Wu, X. L.; Dai, Y. C. Coloured Illustrations of Ganodermataceae of China, Vol. 1, Eds.: Huo, C. Y.; Li, F., Science Press, Beijing, 2005, p. 68 (in Chinese).
[1] 吴兴亮, 戴玉成著, 中国灵芝图鉴, 霍春雁, 李锋, 科学出版社, 2005, p. 68.
[2] Wu X. L. Dai Y. C. Lin Y. H. Guizhou Sci. 2004 22 36.
[2] 吴 兴亮 戴 玉成 林 尤河 贵州科学 2004 22 36.
[3] Zhang S. S. Wang Y. G. Ma Q. Y. Huang S. A. Hu L. L. Yu Z. F. Zhao Y. X. Molecules 2015 20 3281.
[4] Lan, N. N.; Ma, Q. Y.; Kong, F. D.; Yang, N. N.; Xie, Q. Y.; Huang, S. Z.; Wu, Y. G. Zhao, Y. X. Phytochem. Lett. 2017, 22 210.
[5] Zhou X. W. Su K. Q. Zhang Y. M. Appl. Microbiol. Biotechnol. 2012 93 941.
[6] Su H. G. He Y. L. Xiong L. Wang Y. Guo L. Dai O. J. Chin. Med. Mater. 2017 40 2590.
[6] 苏 海国 何 育霖 熊 亮 王 月 郭 力 戴 鸥 中药材 2017 40 2590.
[7] Guo J. Y. Ya L. Y. Yin W. H. Wei l. Yan X. J. Shrestha A. Qing Y. Xiang D. Y. Hui S. PloS One 2015 10 3.
[8] Fang S. D. Chen R. T. Wei B. Y. Chin. Tradit. Herb. Drugs 2007 38 641.
[8] 方 圣鼎 陈 仁通 韦 璧瑜 中草药 2007 38 641.
[9] Martins A. Vasconcelos M. H. Vaz J. A. Martins A. Anti-Cancer Agents Med. Chem. 2010 10 424.
[10] Huang S. Z. Ma Q. Y. Kong F. D. Guo Z. K. Cai L. L. Zhou L. M. Wang Q. Mei W. L. Zhao Y. X. Ivonne N. Helv. Chim. Acta 2010 86 3088.
[11] Ma Q. Y. Luo Y. Huang S. Z. Guo Z. K. Dai H. F. Zhao Y. X. J. Asian Nat. Prod. Res. 2013 15 1214.
[12] Yang H. L. Chen G. H. Li Y. Q. Eur. J. Med. Chem. 2005 40 972.
[13] Liu W. Hu X. Z. Zhu L. Gan J. H. Lu Y. Tao N. P. Wang X. C. Xu C. H. Food Sci. 2019 40 309.
[13] 刘 维 虎 虓真 朱 莉 甘 建红 卢 瑛 陶 宁萍 王 锡昌 许 长华 食品科学 2019 40 309.
[14] Zhou X. Lin J. Yin Y. Zhao J. Sun X. Tang K. Am. J. Chin. Med. 2007 35 559.
[15] Du G. H. Wang H. X. Yan Z. Liu L. Y. Chen R. Y. China J. Chin. Mater. Med. 2017 42 517.
[15] 杜 国华 王 宏旭 闫 征 刘 莉莹 陈 若芸 中国中药杂志 2017 42 517.
[16] Feng L. Yuan L. Du M. Chen Y. Zhang M. H. Gu J. F. He J. J. Wang Y. Cao W. Molecules 2013 18 9961.
[17] Liu J. Q. Lian C. L. Hu T. Y. Wang C. F. Xu Y. Xiao L. Liu Z. Q. Qiu S. Q. Cheng B. H. Food Chem. 2018 263 155.
[18] Shi L. Yu H. P. Zhou Y. Y. Du J. Q. Shen Q. Li J. Y. Li J. Acta Pharmacol. Sin. 2008 29 278.
Options
文章导航

/

〈 〉