研究论文

一种β,β,β-二氟碘-1-苯基乙醇类化合物的简便合成方法

  • 黄国志 ,
  • 任洁 ,
  • 郑笑笑 ,
  • 吴范宏 ,
  • 吴晶晶
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  • 上海应用技术大学化学与环境工程学院 上海 201418

收稿日期: 2019-05-30

  修回日期: 2019-07-28

  网络出版日期: 2019-08-07

基金资助

国家自然科学基金面上(No.21672151)资助项目.

A Convenient Synthesis of β,β-Difluoro-β-iodo-1-phenylethan-1-ols

  • Huang Guozhi ,
  • Ren Jie ,
  • Zheng Xiaoxiao ,
  • Wu Fanhong ,
  • Wu Jingjing
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  • School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418

Received date: 2019-05-30

  Revised date: 2019-07-28

  Online published: 2019-08-07

Supported by

Project supported by the General Project of the National Natural Science Foundation of China (No. 21672151).

摘要

以二氟碘代丙酮类化合物为原料,利用硼氢化钠选择性还原得到高产率的二氟碘代醇类化合物.该合成方法具有反应条件温和,操作简单,产率高等特点,为合成更多的二氟取代醇类化合物试剂提供了简便的途径.

本文引用格式

黄国志 , 任洁 , 郑笑笑 , 吴范宏 , 吴晶晶 . 一种β,β,β-二氟碘-1-苯基乙醇类化合物的简便合成方法[J]. 有机化学, 2019 , 39(12) : 3475 -3482 . DOI: 10.6023/cjoc201905051

Abstract

The synthesis of α,α,α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH4 in methanol at 0℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.

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