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2019 , Vol. 39 >Issue 10: 2936 - 2940

DOI: https://doi.org/10.6023/cjoc201907024

研究简报

Pulchrol和Pulchral的合成研究

  • 郭冬冬 ,
  • 张武霞 ,
  • 高文梅 ,
  • 郭晓迪 ,
  • 王永强
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  • a 山西农业大学文理学院 山西太谷 030801
    b 西北大学化学与材料科学学院 西安 710069

收稿日期: 2019-07-17

  修回日期: 2019-08-20

  网络出版日期: 2019-09-05

基金资助

国家自然科学基金(31800678);山西省青年基金(201801D221062);山西省青年基金(201801D221063);山西省优秀博士来晋工作奖励(SXYBKY201737);山西省优秀博士来晋工作奖励(SXYBKY201706);山西农业大学科技创新基金(Nos. 2017YJ38);山西农业大学科技创新基金(2017YJ41)

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Total Synthesis of Pulchrol and Pulchral

  • Dongdong Guo, ,
  • Wuxia Zhang, ,
  • Weimei Gao, ,
  • Xiaodi Guo, ,
  • Yongqiang Wang,
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  • a College of Arts and Sciences, Shanxi Agricultural University, Taigu 030801, Shanxi
    b Department of Chemistry &Materials Science, Northwest University, Xi'an 710069;

Received date: 2019-07-17

  Revised date: 2019-08-20

  Online published: 2019-09-05

Supported by

Project supported by the National Natural Science Foundation of China(31800678);the Science and Technology Research Project in ShanXi Province(201801D221062);the Science and Technology Research Project in ShanXi Province(201801D221063);the Shanxi Excellent Doctor Grant Award(SXYBKY201737);the Shanxi Excellent Doctor Grant Award(SXYBKY201706);the Science and Technology Innovation Project of Shanxi Agricultural University(Nos. 2017YJ38);the Science and Technology Innovation Project of Shanxi Agricultural University(2017YJ41)

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摘要

以廉价的对苯二酚和4-甲基苯甲酸为原料, 以钯催化芳烃羧酸与芳基溴化物的分子内脱羧偶联为关键反应, 合成了具有抗疟原虫活性的天然产物pulchrol和pulchral, 总收率分别为14%和11%. 该合成为进一步研究构效关系提供了基础.

关键词： 天然产物; 全合成; 交叉偶联; pulchrol; pulchral

本文引用格式

郭冬冬 , 张武霞 , 高文梅 , 郭晓迪 , 王永强 . Pulchrol和Pulchral的合成研究[J]. 有机化学, 2019 , 39(10) : 2936 -2940 . DOI: 10.6023/cjoc201907024

Abstract

The total synthesis of natural products pulchrol and pulchral with antiprotozoan activity was reported, starting from the cheap hydroquinone and 4-methylbenzoic acid and using palladium-catalyzed intramolecular decarboxylation coupling reaction of arene carboxylic acids with aryl bromides as the key reaction. This method provides an opportunity for further study of the structure-activity relationship.

Key words： natural product; total synthesis; cross-coupling; pulchrol; pulchral

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