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2020 , Vol. 40 >Issue 1: 1 - 14

DOI: https://doi.org/10.6023/cjoc201907028

综述与进展

直接二氟甲硫基化与一氟甲硫基化反应研究进展

  • 闫强 ,
  • 蒋绿齐 ,
  • 易文斌
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  • 南京理工大学化工学院 南京 210094

收稿日期: 2019-07-20

  修回日期: 2019-08-29

  网络出版日期: 2019-09-12

基金资助

国家自然科学基金（No.21476116）、中央高校基本科研业务费专项资金（No.30918011314）、江苏省自然科学基金（No.BK20141394）和江苏省青蓝计划和六大高峰人才资助项目.

收起

Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation

  • Yan Qiang ,
  • Jiang Lüqi ,
  • Yi Wenbin
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  • Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094

Received date: 2019-07-20

  Revised date: 2019-08-29

  Online published: 2019-09-12

Supported by

Project supported by the National Natural Science Foundation of China (No. 21476116), the Fundamental Research Funds for the Central Universities (No. 30918011314), the Natural Science Foundation of Jiangsu Province (No. BK20141394) and the Qing Lan and Six Talent Peaks in Jiangsu Province.

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摘要

含有二氟甲硫基基团（SCF2H）与含有一氟甲硫基基团（SCFH2）的有机化合物具有独特的物理和化学性质，在医药及农药等领域具有潜在的应用价值.这两类化合物的传统制备方法是巯基底物的二氟甲基化与一氟甲基化，但含巯基底物本身种类有限，极大地限制了该类化合物的应用与开发，因此开发新的直接二氟/一氟甲硫基化方法和开拓新型直接二氟/一氟甲硫基化试剂具有重要的意义.综述了直接二氟甲硫基化反应和一氟甲硫基化反应的最新研究进展，并对反应的相关机理进行了论述.

关键词： 二氟甲硫基化; 一氟甲硫基化; 直接法

本文引用格式

闫强 , 蒋绿齐 , 易文斌 . 直接二氟甲硫基化与一氟甲硫基化反应研究进展[J]. 有机化学, 2020 , 40(1) : 1 -14 . DOI: 10.6023/cjoc201907028

Abstract

Compounds bearing difluoromethylthio (SCF2H) and monofluoromethylthio (SCFH2) groups are potentially important targets in the pharmaceutical and agrochemical fields due to their unique physical and chemical properties. The traditional methods of synthesizing these two kinds of compounds are difluoromethylation and monofluoromethylation of sulfhydryl substrates. However, the limitation of sulfhydryl substrates also limited the application and development of such compounds. Thus, it is still highly desirable to develop new methods for difluoromethylthiolation and monofluoromethylthiolation as well as new types of difluoromethylthiolation and monofluoromethylthiolation reagents. The recent development of direct difluoromethylthiolation and monofluoromethylthiolation reactions is summarized, and the related mechanism are also discussed.

Key words： difluoromethylthiolation; monofluoromethylthiolation; direct method

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