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2020 , Vol. 40 >Issue 2: 447 - 453

DOI: https://doi.org/10.6023/cjoc201907037

研究论文

醋酸碘苯促进的氧化反应在构建2-氨基-1,3,4-噻二唑分子中的应用

  • 陆雨函 ,
  • 韩颖芝 ,
  • 孙亚栋 ,
  • 阿布力米提·阿布都卡德尔 ,
  • 王多志 ,
  • 刘晨江
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  • 新疆大学化学与化工学院 乌鲁木齐 830046

收稿日期: 2019-07-26

  修回日期: 2019-09-16

  网络出版日期: 2019-10-12

基金资助

国家自然科学基金（Nos.21662032，21562039）和新疆大学博士科研启动基金（No.BS150225）资助项目.

收起

Application of Iodobenzene Acetate Promoted Oxidation in the Synthesis of 2-Amino-1,3,4-thiadiazole Molecules

  • Lu Yuhan ,
  • Han Yingzhi ,
  • Sun Yadong ,
  • Abdukader Ablimit ,
  • Wang Duozhi ,
  • Liu Chenjiang
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  • College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Received date: 2019-07-26

  Revised date: 2019-09-16

  Online published: 2019-10-12

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21662032, 21562039) and the Xinjiang University Doctoral Science Foundation (No. BS150225).

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摘要

报道了一种用高价碘试剂促进缩氨基硫脲分子内氧化偶联反应，能够有效地合成2-氨基-1，3，4-噻二唑类衍生物.高价碘可以作为温和的反应试剂，拥有毒性低、廉价可循环易操作的特性.该反应具有原料易制得、操作简便以及较好的底物适用性等特点.反应机理也进行了初步研究.

关键词： 高价碘; 氧化; 芳香醛; 噻二唑

本文引用格式

陆雨函 , 韩颖芝 , 孙亚栋 , 阿布力米提·阿布都卡德尔 , 王多志 , 刘晨江 . 醋酸碘苯促进的氧化反应在构建2-氨基-1,3,4-噻二唑分子中的应用[J]. 有机化学, 2020 , 40(2) : 447 -453 . DOI: 10.6023/cjoc201907037

Abstract

A highly method for intramolecular oxidative coupling reaction of thiosemicarbazone promoted by hypervalent iodine reagent was reported. 2-Amino-1,3,4-thiadiazole derivatives could be synthesized effectively. Hypervalent iodine could be used as a mild reagent with low toxicity, low cost, easy circulation and operation. The reaction had the advantages of easy preparation of raw materials, simple operation and better performance. The applicability of substrates and the reaction mechanism were also preliminarily studied.

Key words： hypervalent iodine; oxidation; aromatic aldehydes; thiadiazole

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