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2020 , Vol. 40 >Issue 5: 1129 - 1149

DOI: https://doi.org/10.6023/cjoc201911011

综述与进展

1,3-氨基醇的合成研究进展

  • 王伟 ,
  • 胡燚 ,
  • 林睿褀 ,
  • 吴恒 ,
  • 童启 ,
  • 汪连生 ,
  • 肖祖峰 ,
  • 朱磊
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  • 湖北工程学院化学与材料科学学院 湖北孝感 432000

收稿日期: 2019-11-06

  修回日期: 2019-12-11

  网络出版日期: 2020-01-21

基金资助

湖北省教育厅中青年人才（No.Q20172705）、国家自然科学基金（No.21774029）、湖北省高等学校优秀中青年科技创新团队计划（No.T201816）资助项目.

收起

Progress on the Synthesis of 1,3-Amino Alcohol

  • Wang Wei ,
  • Hu Yi ,
  • Lin Ruiqi ,
  • Wu Heng ,
  • Tong Qi ,
  • Wang Liansheng ,
  • Xiao Zufeng ,
  • Zhu Lei
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  • School of Chemistry and Material Science, Hubei Engineering University, Xiaogan, Hubei 432000

Received date: 2019-11-06

  Revised date: 2019-12-11

  Online published: 2020-01-21

Supported by

Project supported by the Hubei Provincial Education Department Young and Middle-aged Talents Project (No. Q20172705), the National Natural Science Foundation of China (No. 21774029), and the Hubei University Excellent Young and Middle-aged Science and Technology Innovation Team Project (No. T201816).

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摘要

具有光学活性的1，3-氨基醇既是有机化学中重要的合成砌块，也是众多生物活性分子的核心结构，因此不对称合成1，3-氨基醇一直是合成领域的一个热点.从aldol缩合或azo-aldol缩合合成，过渡金属催化C—H键活化、氨化合成，氮杂环的开环-加成合成，[3+2]偶极环加成反应等方面综述了近年来所发展的1，3-氨基醇的合成方法及进展.

关键词： 1,3-氨基醇; 不对称合成; 催化剂

本文引用格式

王伟 , 胡燚 , 林睿褀 , 吴恒 , 童启 , 汪连生 , 肖祖峰 , 朱磊 . 1,3-氨基醇的合成研究进展[J]. 有机化学, 2020 , 40(5) : 1129 -1149 . DOI: 10.6023/cjoc201911011

Abstract

Optically pure 1,3-amino alcohol is not only the important synthon in organic synthesis, but also the core structure of numerous bioactive molecule. As a result, the formation of 1,3-amino alcohols occupies a hot resarch topic in asymmetric synthesis. This review symmarizes several types of frequently-used methods and progress on synthesizing 1,3-amino alcohols:aldol or azo-aldol condensation synthesis, transition metal catalyzed C-H activation and amination synthesis, ring-opening and addition of azocyclic compounds, and[3+2] dipolar-cycloaddition reaction etc.

Key words： 1,3-amino alcohol; asymmetric synthesis; catalyst

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