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2020 , Vol. 40 >Issue 3: 551 - 562

DOI: https://doi.org/10.6023/cjoc201911007

综述与进展

多环型Xanthone类天然产物的合成研究进展

  • 谢涛 ,
  • 何海兵 ,
  • 高栓虎
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  • a 华东师范大学化学与分子工程学院 上海绿色化学与化工工程绿色化重点实验室 上海 200062;
    b 华东师范大学 上海分子治疗与新药创制工程技术研究中心 上海 200062

收稿日期: 2019-11-06

  修回日期: 2019-11-26

  网络出版日期: 2020-04-02

基金资助

国家自然科学基金（Nos.21971068，21772044）、上海市优秀学术/技术带头人计划（No.18XD1401500）、上海市科委基础研究项目（No.18JC1411303）、教育部创新团队和中央高校基本科研业务费专项资金资助项目.

收起

Synthetic Progress of Polycyclic Xanthone

  • Xie Tao ,
  • He Haibing ,
  • Gao Shuanhu
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  • a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062;
    b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062

Received date: 2019-11-06

  Revised date: 2019-11-26

  Online published: 2020-04-02

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21971068, 21772044), the Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500), the Program of Shanghai Science and Technology Committee (No. 18JC1411303), the National Young Top-Notch Talent Support Program and the Fundamental Research Funds for the Central Universities.

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摘要

多环型xanthone类天然产物是一类具有高度氧化态和六环骨架结构的天然产物.目前分离得到的此类化合物主要来源于放线菌.由于这类化合物具有结构特独、广泛的抗细菌活性、一定程度的抗真菌活性以及良好的抗肿瘤活性，吸引了大量有机合成和药物化学等领域学者的关注.近十年来，相关的生物和化学合成以及药物化学研究报道明显增多，主要总结了多环型xanthone类天然产物的合成研究进展.

关键词： 多环型xanthone; 天然产物; 全合成

本文引用格式

谢涛 , 何海兵 , 高栓虎 . 多环型Xanthone类天然产物的合成研究进展[J]. 有机化学, 2020 , 40(3) : 551 -562 . DOI: 10.6023/cjoc201911007

Abstract

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated angular hexacyclic frameworks. In the last decade, there has been a noticeable increase in reports on both synthetic and pharmacological investigations of this class of natural molecules due to their unique chemical structures and biological activities. Most members of this class of molecules show strong activities towards Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, potent antifungal activity and antitumour activity. The synthetic studies of some members of this class of natural products is summarized.

Key words： polycyclic xanthone; natural product; total synthesis

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