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2020 , Vol. 40 >Issue 7: 1901 - 1911

DOI: https://doi.org/10.6023/cjoc202001012

综述与进展

三氟甲基季碳中心的合成进展

  • 王守锋 ,
  • 王文贵
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  • 济南大学化学化工学院 山东省氟化学化工材料重点实验室 济南 250022

收稿日期: 2020-01-07

  修回日期: 2020-03-24

  网络出版日期: 2020-04-10

基金资助

国家自然科学基金（No.31972850）和山东省重点研发计划（No.2019GSF108223）资助项目.

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Recent Advances of the Construction of Trifluoromethylated Quaternary Carbon Center

  • Wang Shoufeng ,
  • Wang Wengui
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  • Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022

Received date: 2020-01-07

  Revised date: 2020-03-24

  Online published: 2020-04-10

Supported by

Project supported by the National Natural Science Foundation of China (No. 31972850) and the Shandong Provincial Key Research Program (No. 2019GSF108223).

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摘要

三氟甲基是一个重要的含氟基团，常被应用于药物和农药领域.季碳中心是广泛存在于天然产物和合成药物中的结构.近年来，构建含有三氟甲基季碳中心的分子得到了快速发展.从直接三氟甲基化反应、新的合成砌块和新反应的探索几个方面，综述了近十年来合成三氟甲基季碳中心的研究进展.

关键词： 三氟甲基; 季碳中心; 合成进展

本文引用格式

王守锋 , 王文贵 . 三氟甲基季碳中心的合成进展[J]. 有机化学, 2020 , 40(7) : 1901 -1911 . DOI: 10.6023/cjoc202001012

Abstract

Trifluoromethyl is an important group, which is often used in pharmecuticals and agrochemicals. Quaternary carbon centers are widely existed in natural products and synthetic compounds. Recently, the construction of molecules containing trifluoromethylated quaternary carbon centers has been developed rapidly. Starting with direct trifluoromethylation, new synthons and new reactions, the research progress of the synthesis of trifluoromethylated quaternary carbon centers is reviewed.

Key words： trifluoromethyl; quaternary carbon center; research progress

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