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2020 , Vol. 40 >Issue 7: 2148 - 2152

DOI: https://doi.org/10.6023/cjoc201912037

研究简报

鸟巢烷二萜关键中间体的合成

  • 李若馨 ,
  • 韩锐 ,
  • 高锦明
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  • 西北农林科技大学化学与药学院 陕西省天然产物化学生物学重点实验室 陕西杨陵 712100

收稿日期: 2019-12-25

  修回日期: 2020-04-09

  网络出版日期: 2020-04-23

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Synthesis of Key Intermediate of Cyathane Diterpenes

  • Li Ruoxin ,
  • Han Rui ,
  • Gao Jinming
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  • Shanxi Key Laboratory of Natural Products Chemistry and Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100

Received date: 2019-12-25

  Revised date: 2020-04-09

  Online published: 2020-04-23

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摘要

开发了一种鸟巢烷型二萜类天然产物关键二环[5/6]中间体的合成策略，该策略涉及亲核取代反应、自由基关环反应、Johnson-Claisen重排和格氏加成等一系列反应，并对反应条件进行优化.该路线具有高效、简洁的优点，在此类天然产物的全合成中有较大的应用潜力.

关键词： 鸟巢烷型二萜; 天然产物; 亲核取代; Claisen重排

本文引用格式

李若馨 , 韩锐 , 高锦明 . 鸟巢烷二萜关键中间体的合成[J]. 有机化学, 2020 , 40(7) : 2148 -2152 . DOI: 10.6023/cjoc201912037

Abstract

A synthetic plan of bicyclo[5/6] key intermediate of cyathane is reported. All the involved reactions, such as nucleophilic substitution reaction, radical ring-closing reaction, Johnson-Claisen rearrangement and Grignard addition, were optimized for higher yields. The procedure provides a simple and efficient method for the synthesis of bicyclo-key intermediate of cyathane. It is expected to have wide applications in the synthesis of cyathane.

Key words： cyathane diterpenes; natural product; nucleophilic substitution; Claisen rearrangement

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