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2020 , Vol. 40 >Issue 7: 1999 - 2007

DOI: https://doi.org/10.6023/cjoc202003029

研究论文

四氢呋喃螺氧化吲哚衍生物的一锅法高效合成

  • 郭欣 ,
  • 郭亚军 ,
  • 孔德志 ,
  • 卢会杰 ,
  • 华远照 ,
  • 王敏灿
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  • 郑州大学化学学院 绿色催化研究所 郑州 450000

收稿日期: 2020-03-11

  修回日期: 2020-04-20

  网络出版日期: 2020-04-30

基金资助

国家自然科学基金（No.21272216）、中国博士后科学基金（No.2017M622361）和河南省教育厅（Nos.17B150014，18B150028）资助项目.

收起

Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction

  • Guo Xin ,
  • Guo Yajun ,
  • Kong Dezhi ,
  • Lu Huijie ,
  • Hua Yuanzhao ,
  • Wang Mincan
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  • Institute of Green Catalysis, College of Chemistry, Zhengzhou University, Zhengzhou 450000

Received date: 2020-03-11

  Revised date: 2020-04-20

  Online published: 2020-04-30

Supported by

Project supported by the National Natural Science Foundation of China (No. 21871237), the China Postdoctoral Science Foundation (No:2017M622361) and the Education Department of Henan Province (Nos. 17B150014, 18B150028).

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摘要

报道了α-羟基芳基酮和β，γ-不饱和-α-酮酰胺发生的Michael/半缩酮化和傅-克（Friedel-Crafts）反应的两步一锅反应.该方法利用不包含氧化吲哚和四氢呋喃结构的链状底物，高效构建出包含螺碳原子、氧化吲哚环和四氢呋喃环的四氢呋喃螺氧化吲哚衍生物.

关键词： 一锅法; 串联反应; 四氢呋喃螺氧化吲哚

本文引用格式

郭欣 , 郭亚军 , 孔德志 , 卢会杰 , 华远照 , 王敏灿 . 四氢呋喃螺氧化吲哚衍生物的一锅法高效合成[J]. 有机化学, 2020 , 40(7) : 1999 -2007 . DOI: 10.6023/cjoc202003029

Abstract

A one-pot reaction of Michael/hemiketalization and Fridel-Crafts reaction of α-hydroxy aryl ketones and β,γ-unsaturated α-ketoamides has been developed. The process enables efficient synthesis of tetrahydrofuran spirooxindoles using chain substrates that do not contain oxindole and tetrahydrofuran skeletons. A spiro-carbon center, an oxindole ring and a tetrahydrofuran ring, are constructed in this process.

Key words： one-pot; cascade reaction; tetrahydrofuran spirooxindoles

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