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2020 , Vol. 40 >Issue 7: 2120 - 2126

DOI: https://doi.org/10.6023/cjoc202003021

研究简报

长苞铁杉中木脂素类化学成分研究

  • 刘贵园 ,
  • 郭大乐 ,
  • 邓赟 ,
  • 令狐浪 ,
  • 张茂生 ,
  • 何芋歧 ,
  • 肖世基
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  • a 遵义医科大学药学院 贵州遵义 563006;
    b 成都中医药大学药学院 成都 611137

收稿日期: 2020-03-08

  修回日期: 2020-04-23

  网络出版日期: 2020-05-08

基金资助

国家自然科学基金（No.31560102）资助项目

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Lignans from the Heartwood of Nothotsuga longibracteata

  • Liu Guiyuan ,
  • Guo Dale ,
  • Deng Yun ,
  • Linghu Lang ,
  • Zhang Maosheng ,
  • He Yuqi ,
  • Xiao Shiji
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  • a School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563006;
    b School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137

Received date: 2020-03-08

  Revised date: 2020-04-23

  Online published: 2020-05-08

Supported by

Project supported by the National Natural Science Foundation of China (No. 31560102).

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摘要

从中国特有植物长苞铁杉心材中分离纯化得到1个新的苄基呋喃酮衍生物（1），2个新的木脂素（2，3），以及19个已知的木脂素类化合物，新化合物的结构通过HR-ESI-MS，1D NMR，2D NMR，CD等光谱技术分别鉴定为3-（4'-羟基-3'-甲氧基苄基）-2（5H）-呋喃酮（1），（8S，8'S）-3，3'-二甲氧基木脂-4，4'，9，9'-四醇-9-乙酸酯（2），（7'R，8S，8'S）-3'，5-二甲氧基-2，7'-环木脂-4，4'，9'-三醇-9-酸丁酯.噻唑蓝（MTT）法测试显示新化合物对三种肿瘤细胞（A172，SHSY5Y，Hela）均未表现出明显毒性.斑马鱼肠胃蠕动活性测试显示，化合物3在8和24 μmol/L浓度下对斑马鱼肠胃蠕动有明显的促进作用.

关键词： 松科; 长苞铁杉; 苄基呋喃酮; 木脂素

本文引用格式

刘贵园 , 郭大乐 , 邓赟 , 令狐浪 , 张茂生 , 何芋歧 , 肖世基 . 长苞铁杉中木脂素类化学成分研究[J]. 有机化学, 2020 , 40(7) : 2120 -2126 . DOI: 10.6023/cjoc202003021

Abstract

3-(4'-Hydroxy-3'-methoxybenzyl)-2(5H)-furanone (1), a rare benzyl furanone derivate, and two new lignans (2 and 3) were isolated from the heartwood of Nothotsuga longibracteata, together with nineteen known lignans compounds. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESI-MS, 1D NMR, 2D NMR, and CD spectroscopies. The cytotoxic effects of the isolated new lignan compounds on three human tumour cell lines (A172, SHSY5Y, and Hela) were evaluated by methyl thiazolyl tetrazolium (MTT) assay. Their showed no cytotoxic activities at the concentration of 50 μmol/L. Gastrointestinal motility test of zebrafish showed that compound 3 has the function of promoting gastrointestinal motility of zebrafish to excrete Nile red at doses 8 and 24 μmol/L by means of acting on the cholinergic nervous system.

Key words： pinaceae; Nothotsuga longibracteata; benzyl furanone; lignans

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