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2020 , Vol. 40 >Issue 9: 2988 - 2993

DOI: https://doi.org/10.6023/cjoc202003043

研究简报

低共熔溶剂促进N-取代十氢吖啶-1,8-二酮类化合物的合成

  • 肖立伟 ,
  • 刘光仙 ,
  • 李政 ,
  • 任萍 ,
  • 任丽磊 ,
  • 孔洁
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  • 廊坊师范学院化学与材料科学学院 河北廊坊 065000

收稿日期: 2020-03-16

  修回日期: 2020-05-22

  网络出版日期: 2020-06-19

基金资助

河北省教育厅（Nos.ZD2020153，ZD2019036）和廊坊市科技局（No.2019011018）资助项目.

收起

Synthesis of N-Substituted Decahydroacridine-1,8-diones Promoted by Deep Eutectic Solvents

  • Xiao Liwei ,
  • Liu Guangxian ,
  • Li Zheng ,
  • Ren Ping ,
  • Ren Lilei ,
  • Kong Jie
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  • College of Chemistry and Material Science, Langfang Normal University, Langfang, Hebei 065000

Received date: 2020-03-16

  Revised date: 2020-05-22

  Online published: 2020-06-19

Supported by

Project supported by the Educational Commission of Hebei Province (Nos. ZD2020153, ZD2019036) and the Science and Technology Bureau of Langfang City (No. 2019011018).

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摘要

在氯化胆碱-氯化锌（ChCl/ZnCl2）组成的低共熔溶剂（DES）中，80~90℃条件下，双酮、芳醛与醋酸铵或芳胺反应1~2 h，合成了一系列十氢吖啶1，8-二酮以及N-取代十氢吖啶-1，8-二酮类化合物，产率达75%~92%.该方法反应条件温和、操作简单、反应时间短、产率较高、对环境友好.

关键词： 低共熔溶剂; 十氢吖啶-1,8-二酮; 多组分反应; 绿色化学

本文引用格式

肖立伟 , 刘光仙 , 李政 , 任萍 , 任丽磊 , 孔洁 . 低共熔溶剂促进N-取代十氢吖啶-1,8-二酮类化合物的合成[J]. 有机化学, 2020 , 40(9) : 2988 -2993 . DOI: 10.6023/cjoc202003043

Abstract

In the deep eutectic solvents (DES) consisted of choline chloride/zinc chloride(ChCl/ZnCl2), a series of N-substi-tuted decahydroacridine-1,8-diones and decahydroacridine-1,8-diones were synthesized from diketones, aromatic aldehydes, ammonium acetates or aromatic amines with 75%~92% yields at 80~90 ℃ in 1~2 h. The advantages of the method are wild reaction condition, simple operation, short reaction time, high yield and friendly to environment.

Key words： deep eutectic solvent; decahydroacridine-1,8-diones; multicomponent reaction; green chemistry

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