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2020 , Vol. 40 >Issue 9: 2626 - 2640

DOI: https://doi.org/10.6023/cjoc202004002

综述与进展

串联环化反应合成噻吩并[2,3-d]嘧啶类化合物的研究进展

  • 孙晓华 ,
  • 孙传策 ,
  • 冯立军 ,
  • 康从民
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  • 青岛科技大学化工学院 山东青岛 266042

收稿日期: 2020-04-01

  修回日期: 2020-05-31

  网络出版日期: 2020-06-19

基金资助

国家自然科学基金（No.21272131）资助项目.

收起

Recent Progress in the Synthesis of Thieno[2,3-d]pyrimidine Compounds via Tandem Cyclization

  • Sun Xiaohua ,
  • Sun Chuance ,
  • Feng Lijun ,
  • Kang Congmin
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  • College of Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao, Shandong 266042

Received date: 2020-04-01

  Revised date: 2020-05-31

  Online published: 2020-06-19

Supported by

Project supported by the National Natural Science Foundation of China (No. 21272131).

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摘要

噻吩并[2，3-d]嘧啶类化合物是一类重要的有机合成中间体和药理活性分子，具有广阔的医药应用前景和重要的研究意义，因此其合成也备受关注.现有的合成方法主要是通过串联环化反应或一锅多组分反应，结合微波辅助法或新型催化剂以达到缩短反应时间、减少反应步骤、提高产率、降低成本等目的.较全面地概述了近十年来，特别是近五年来通过串联环化反应合成噻吩并[2，3-d]嘧啶类化合物的研究进展，对该领域存在的问题和局限性进行了总结，并对今后的发展作出展望，以期对相关领域的研究起到一定的辅助和推动作用.

关键词： 噻吩并[2,3-d]嘧啶; 串联环化反应; 微波反应; 一锅多组分反应

本文引用格式

孙晓华 , 孙传策 , 冯立军 , 康从民 . 串联环化反应合成噻吩并[2,3-d]嘧啶类化合物的研究进展[J]. 有机化学, 2020 , 40(9) : 2626 -2640 . DOI: 10.6023/cjoc202004002

Abstract

Thieno[2,3-d]pyrimidine compounds are an important class of organic synthesis intermediates and pharmacologically active molecules, which not only have broad medical application prospect, but also worth researching. Therefore the synthesis of them has attracted much attention. The previous methods mainly apply tandem cyclization or one-pot multi-com-ponent reaction combined with microwave-assisted reaction or new catalysts to reach the purpose of shortening reaction time, reducing steps, enhancing yields and lowering costs. In this paper, the recent progress in the synthesis of thieno[2,3-d]pyri-midine compounds via tandem cyclization in recent ten years, especially in the latest five years, is reviewed. The problems and limitations faced are discussed, and the development directions are also prospected.

Key words： thieno[2,3-d]pyrimidine; tandem cyclization; microwave reaction; one-pot multi-component reaction

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