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2020 , Vol. 40 >Issue 9: 2778 - 2787

DOI: https://doi.org/10.6023/cjoc202005051

研究论文

一类线性β,γ-不饱和α-酮酸色醇酯类化合物的合成

  • 余接强 ,
  • 贾俊 ,
  • 王兴旺
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  • a 苏州大学材料与化学化工学部 江苏苏州 215123;
    b 苏州大学分析测试中心 江苏苏州 215123

收稿日期: 2020-05-19

  修回日期: 2020-06-22

  网络出版日期: 2020-07-09

基金资助

国家自然科学基金（No.21971176）资助项目.

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Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds

  • Yu Jieqiang ,
  • Jia Jun ,
  • Wang Xingwang
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  • a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123;
    b Analysis and Testing Center, Soochow University, Suzhou, Jiangsu 215123

Received date: 2020-05-19

  Revised date: 2020-06-22

  Online published: 2020-07-09

Supported by

Project supported by the National Natural Science Foundation of China (No. 21971176).

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摘要

色醇类衍生物是一类十分重要的化合物，具有广谱的药理和生理活性.报道了以1-（3-二甲氨基丙基）-3-乙基碳二亚胺盐酸盐（EDCI）和1-羟基苯并三唑（HOBt）作为缩合试剂，在温和的条件下对各种取代的色醇与β，γ-不饱和α-酮酸进行的缩合酯化反应，制备了一系列β，γ-不饱和-α-酮酸色醇酯类化合物.该方法底物适应性广，原料易得且操作简便.

关键词： 缩合试剂; 色醇; 酯化; β,γ-不饱和α-酮酸; β,γ-不饱和-α-酮酸色醇酯

本文引用格式

余接强 , 贾俊 , 王兴旺 . 一类线性β,γ-不饱和α-酮酸色醇酯类化合物的合成[J]. 有机化学, 2020 , 40(9) : 2778 -2787 . DOI: 10.6023/cjoc202005051

Abstract

Tryptophol derivatives are very important compounds with wide spectrum of pharmaceutical and physiological activity. Herein, the esterification reaction of trypthol and its derivatives with β,γ-unsaturated α-keto acids was reported by the use of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole (HOBt) as conden-sation reagents. A series of β,γ-unsaturated α-keto trypanol ester derivatives were prepared in moderate to high yields. This method has advantages of riched functional group tolerance, readily available starting materials and easy operation.

Key words： condensation reagent; tryptophol; esterification; β,γ-unsaturated α-keto acid; β,γ-unsaturated α-keto trypanol ester

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