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2020 , Vol. 40 >Issue 12: 3991 - 4014

DOI: https://doi.org/10.6023/cjoc202006024

综述与进展

叔丁基亚磺酰胺在天然产物全合成中的应用

  • 李颖 ,
  • 马志强 ,
  • 徐学涛
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  • a 五邑大学生物科技与大健康学院 广东江门 529020;
    b 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510641

收稿日期: 2020-06-15

  修回日期: 2020-07-23

  网络出版日期: 2020-08-01

基金资助

广东省教育厅基金基金（No.2019KZDXM035）资助项目.

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Application of tert-Butanesulfinamide in Total Synthesis of Natural Products

  • Li Ying ,
  • Ma Zhiqiang ,
  • Xu Xuetao
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  • a School of Biotechnology and Health Science, Wuyi University, Jiangmen, Guangdong 529020;
    b Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641

Received date: 2020-06-15

  Revised date: 2020-07-23

  Online published: 2020-08-01

Supported by

Project supported by the Department of Education of Guangdong Province (No. 2019KZDXM035).

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摘要

叔丁基亚磺酰胺由于性质稳定、商业可得、价格合理、使用方便及参与反应的立体选择性好等优点，受到化学家的广泛关注.总结了近年来利用手性叔丁基亚磺酰胺作为手性辅基诱导生成手性胺中间体在天然产物不对称全合成中的应用，主要分亲核试剂对叔丁基亚磺酰亚胺的加成及叔丁基亚磺酰基金属烯胺对亲电试剂的加成两部分进行介绍.

关键词： 叔丁基亚磺酰胺; 手性胺; 全合成

本文引用格式

李颖 , 马志强 , 徐学涛 . 叔丁基亚磺酰胺在天然产物全合成中的应用[J]. 有机化学, 2020 , 40(12) : 3991 -4014 . DOI: 10.6023/cjoc202006024

Abstract

The formation of chiral amine intermediates with chiral tert-butanesulfinamide and their applications in asymmetric natural product synthesis in recent years are summarized. tert-Butanesulfinamide has attracted wide attention from chemists because it is stable, commercially available with reasonable price, ease to use, and usually induces high diastereoselectivity in the reactions involved. This review is divided into two sections, including the addition of nucleophiles to N-tert-butanesulfinyl imines and the addition of N-tert-butanesulfinyl metalloenamines to electrophiles.

Key words： tert-butanesulfinamide; chiral amine; total synthesis

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