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2020 , Vol. 40 >Issue 12: 4258 - 4266

DOI: https://doi.org/10.6023/cjoc202005077

研究论文

可见光催化分子内环芳构化合成10-菲酚衍生物

  • 滕巧玲 ,
  • 许露露 ,
  • 程冬萍 ,
  • 许孝良
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  • a 浙江工业大学化学工程学院 杭州 310014;
    b 浙江工业大学药学院 杭州 310014

收稿日期: 2020-05-28

  修回日期: 2020-07-21

  网络出版日期: 2020-08-06

基金资助

浙江省自然科学基金（Nos.LY18B020018，LY15B020004）和国家自然科学基金（No.21602197）资助项目.

收起

Synthesis of 10-Phenanthrenol Derivatives via Visible Light Catalyzed Itramolecular Cycloaromatization

  • Teng Qiaoling ,
  • Xu Lulu ,
  • Cheng Dongping ,
  • Xu Xiaoliang
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  • a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
    b College of Pharmaceutical, Zhejiang University of Technology, Hangzhou 310014

Received date: 2020-05-28

  Revised date: 2020-07-21

  Online published: 2020-08-06

Supported by

Project supported by the Zhejiang Provincial Natural Science Foundation (Nos. LY18B020018, LY15B020004) and the National Natural Science Foundation of China (No. 21602197).

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摘要

菲衍生物在药物化学和材料科学中具有重要的地位.可见光催化具有绿色、反应条件温和、应用潜力大等优点，已经逐渐成为有机合成中的有力工具.报道了以Ir[dF（CF3）ppy]2（dtbbpy）PF6为可见光催化剂，2-芳基苯甲酰乙酸衍生物发生分子内环芳构化反应，以中等至良好的收率得到一系列10-菲酚衍生物.此外，对该反应的机理进行了推测.

关键词： 可见光催化剂; 自由基反应; 分子内环芳构化; 菲酚

本文引用格式

滕巧玲 , 许露露 , 程冬萍 , 许孝良 . 可见光催化分子内环芳构化合成10-菲酚衍生物[J]. 有机化学, 2020 , 40(12) : 4258 -4266 . DOI: 10.6023/cjoc202005077

Abstract

Phenanthrene derivatives play an important role in pharmaceutical chemistry and material science. Due to its advantages of green, mild reaction conditions and great application potential, visible light catalysis has become a powerful tool in organic synthesis. In this paper, under the catalysis of photocatalyst Ir[dF(CF3)ppy]2(dtbbpy)PF6, a series of 10-phenanthrenol derivatives were synthesized from 2-arylbenzoyl acetate derivatives in moderate to good yields through intramolecular cycloaromatization. In addition, the plausible reaction mechanism was also proposed.

Key words： visible-light photocatalysis; radical reaction; intramolecular cycloaromatization; phenanthrenols

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