碱促进下空气氧化制备 α-芳甲酰基硫代酰胺的便捷方法
收稿日期: 2020-06-04
修回日期: 2020-07-30
网络出版日期: 2020-08-19
基金资助
国家自然科学基金(81560559); 国家自然科学基金(81703356); 贵州省教育厅自然科学基金(黔教合KY字[2021]161); 贵州省科技厅社发公关(黔科合SY[2015]3030); 贵州省卫健委科学技术基金(gzwjk2019-1-179); 贵州医科大学博士后流动站资助项目.
Convenient Method for Preparingα-Ketoarylthioamide by Air Oxidation under Base Conditions
Received date: 2020-06-04
Revised date: 2020-07-30
Online published: 2020-08-19
Supported by
the National Natural Science Foundation of China(81560559); the National Natural Science Foundation of China(81703356); the Natural Science Research Fund of Guizhou Education Department(黔教合KY字[2021]161); the Scientific and Technological Foundation of Guizhou Health Committee(gzwjk2019-1-179); the Mobile Postdoctoral Center of Guizhou Medical University
报道了一种实用的空气氧化制备 α-芳甲酰基硫代酰胺的方法. 在空气氛围下, 以K2CO3为碱, 二甲基亚砜(DMSO)为溶剂, 120 ℃条件下 α-苄基硫代酰胺经氧化以42%~85%的产率得到 α-芳甲酰基硫代酰胺. 该反应无需金属参与, 具有良好的底物适用性和原子经济性, 为 α-芳甲酰基硫代酰胺的合成提供了一种高效、经济、绿色、简便的方法.
关键词： 空气; 二甲基亚砜(DMSO); K2CO3; 绿色氧化; α-芳甲酰基硫代酰胺
王聪 , 姚瑶瑶 , 谢珺 , 王建塔 , 王飞清 , 张吉泉 , 汤磊 . 碱促进下空气氧化制备 α-芳甲酰基硫代酰胺的便捷方法[J]. 有机化学, 2021 , 41(1) : 370 -375 . DOI: 10.6023/cjoc202002011
A practical method for preparing α-ketoaryl thioamide by air oxidation has been developed. Under air atmosphere, in the presence of K2CO3 as base and dimethyl sulfoxide (DMSO) as solvent at 120 ℃, a variety of α-ketoarylthioamides were obtained from aryl thioamide in yields of 42%~85%. This reaction has good substrate applicability, metal-free and atomic economy, and provides an efficient, economical, green and convenient method for the synthesis of α-ketoaryl thioamide.
Key words： air; dimethyl sulfoxide (DMSO); K2CO3; green oxidation; α-ketoaryl thioamide
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