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2021 , Vol. 41 >Issue 1: 12 - 51

DOI: https://doi.org/10.6023/cjoc202007045

综述与进展

通过环加成反应和串联反应构建桥环化合物的研究进展

  • 王乐乐 ,
  • 张子莹 ,
  • 韩华彬 ,
  • 刘雄利 ,
  • 卜站伟 ,
  • 王琪琳
展开
  • a 河南大学化学化工学院 河南开封 475004
    b 贵州大学贵州药食植物资源研究开发中心 贵阳 550025
* Corresponding author. E-mail:

收稿日期: 2020-07-18

  修回日期: 2020-08-29

  网络出版日期: 2020-09-16

基金资助

国家自然科学基金(U1504206); 中国博士后科学基金(2020M672200); 河南大学(SYL19060137); 河南大学(SYL19030204)

收起

Recent Advances in the Construction of Bridged Rings through Cycloadditions and Cascade Reactions

  • Lele Wang ,
  • Ziying Zhang ,
  • Huabin Han ,
  • Xiongli Liu ,
  • Zhanwei Bu ,
  • Qilin Wang
Expand
  • a College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004
    b Guizhou Medicine Edible Plant Resources Research and Development Center, Guizhou University, Guiyang 550025

Received date: 2020-07-18

  Revised date: 2020-08-29

  Online published: 2020-09-16

Supported by

the National Natural Science Foundation of China(U1504206); the China Postdoctoral Science Foundation(2020M672200); the Henan University(SYL19060137); the Henan University(SYL19030204)

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摘要

桥环化合物广泛存在于天然产物和具有重要生理活性的分子中, 在药物化学、天然产物化学、合成化学、材料化学及生命科学等领域具有重要的应用价值. 近年来, 经过广大化学工作者的不懈努力, 已发展了系列高效构建桥环化合物的新方法. 从环加成反应和串联反应两种策略出发, 详细介绍近五年来用于构建桥环化合物的方法及最新研究进展, 简要分析目前方法的优势及存在的问题, 以期为从事有机合成及相关领域的研究者提供有益借鉴和参考.

关键词： 桥环化合物; 环加成; 串联反应

本文引用格式

王乐乐 , 张子莹 , 韩华彬 , 刘雄利 , 卜站伟 , 王琪琳 . 通过环加成反应和串联反应构建桥环化合物的研究进展[J]. 有机化学, 2021 , 41(1) : 12 -51 . DOI: 10.6023/cjoc202007045

Abstract

Bridged rings are frequently encountered in natural products and biologically active molecules, which have significant application in the field of medicinal chemistry, natural product chemistry, synthetic chemistry, material chemistry and life science. In recent years, with the unremitting efforts of a large number of chemists, a series of new methods have been developed for the efficient synthesis of bridged compounds. The detailed synthetic methods to access bridged compounds in the past five years involving cycloadditions and cascade reactions are summarized, and the advantages and problems of the current methods are briefly analyzed, which would provide useful reference for the researchers engaged in organic synthesis and related fields.

Key words： Keywords bridged ring; cycloaddition; cascade reaction

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