铜催化加成/取代串联反应构建四取代的三吲哚甲烷
收稿日期: 2020-07-23
修回日期: 2020-08-21
网络出版日期: 2020-09-22
基金资助
国家自然科学基金(U1504206); 中国博士后科学基金(2020M672200); 河南大学研究生教育创新与质量提升计划(SYL19060137); 河南大学研究生教育创新与质量提升计划(SYL19030204)
Access to Tetrasubstituted Tri(indolyl)methanes through Copper-Catalyzed Addition/Substitution Sequence
Received date: 2020-07-23
Revised date: 2020-08-21
Online published: 2020-09-22
Supported by
the National Natural Science Foundation of China(U1504206); the China Postdoctoral Science Foundation(2020M672200); the Graduate Education Innovation and Quality Improvement Program of Henan University(SYL19060137); the Graduate Education Innovation and Quality Improvement Program of Henan University(SYL19030204)
王文博 , 韩华彬 , 王乐乐 , 王琪琳 , 卜站伟 . 铜催化加成/取代串联反应构建四取代的三吲哚甲烷[J]. 有机化学, 2021 , 41(2) : 757 -765 . DOI: 10.6023/cjoc202007055
An efficient one-pot synthesis of highly crowded tetrasubstituted tri(indolyl)methanes has been achieved through the addition/substitution sequence of 3-acetylindoles and indoles under mild conditions. The key to the success was improving the reactivity of 3-acetylindoles by rationally installing the N-protecting groups. The salient features including easily accessible and low-cost starting materials, board substrate scope, simple operation and structurally useful products make this approach particularly attractive.
Key words： indole; tri(indolyl)methane; cascade reaction
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