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2021 , Vol. 41 >Issue 2: 795 - 805

DOI: https://doi.org/10.6023/cjoc202006077

研究论文

杂芳基烷基醚、杂芳基卤化物与(氘代)醇的亲核醚化

  • 王霞 ,
  • 屈益欣 ,
  • 龙城宇 ,
  • 王雪强
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  • 1 湖南大学化学化工学院 分子科学与生物医学实验室(MBL) 化学/生物传感与化学计量家重点实验室 长沙 410082
* Corresponding author. E-mail:
† 共同第一作者(These authors contributed equally to this work).

收稿日期: 2020-06-30

  修回日期: 2020-08-20

  网络出版日期: 2020-10-12

基金资助

湖南省湖湘青年人才计划(2019RS2022)

收起

Nucleophilic Etherification of Heteroaryl Alkyl Ethers, Heteroaryl Halides with (Deuterated) Alcohols

  • Xia Wang ,
  • Yixin Qu ,
  • Chengyu Long ,
  • Xue-Qiang Wang
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  • 1 Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082

Received date: 2020-06-30

  Revised date: 2020-08-20

  Online published: 2020-10-12

Supported by

the Huxiang Young Talent Program from Hunan Province(2019RS2022)

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摘要

研究了在叔丁醇钾的作用下, 杂芳基烷氧化合物、杂芳基卤化物和杂芳基硫醚与各种伯、仲、叔脂肪醇高效醚化, 强调了天然产物和生物活性分子的衍生化以及不易通过其他途径获得的氘代芳基烷基醚的合成方法的实用性.

关键词： 醚化; 杂芳基烷基醚; 芳香亲核取代

本文引用格式

王霞 , 屈益欣 , 龙城宇 , 王雪强 . 杂芳基烷基醚、杂芳基卤化物与(氘代)醇的亲核醚化[J]. 有机化学, 2021 , 41(2) : 795 -805 . DOI: 10.6023/cjoc202006077

Abstract

A KOt-Bu empowered transition-metal free and efficient procedure for the etherification of alkoxy heteroarenes, heteroaryl halides and heteroaryl thioethers with various primary, secondary, tertiary aliphatic alcohols has been developed. The usefulness of our method is highlighted by the derivatization of natural products and bioactive molecules, and the synthesis of deuterated heteroaryl alkyl ethers that are not easy to access via other approaches.

Key words： etherification; heteroaryl alkyl ethers; nucleophilic aromatic substitution

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