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2020 , Vol. 40 >Issue 12: 4015 - 4030

DOI: https://doi.org/10.6023/cjoc202008042

综述与进展

N-取代-1,2,3-三氮唑化合物的合成研究进展

  • 刘启顺 ,
  • 吕玉芬 ,
  • 鲍鹏丽 ,
  • 岳会兰 ,
  • 魏伟
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  • a 曲阜师范大学化学与化工学院 山东曲阜 273165;
    b 中国科学院西北高原生物研究所 中国科学院藏药研究重点实验室 西宁 810008

收稿日期: 2020-08-24

  修回日期: 2020-09-28

  网络出版日期: 2020-10-15

基金资助

山东省高校青创科技计划（No.2019KJC021）、国家自然科学基金（No.ZR2018MB009）、青海省国际合作专项（No.2018-HZ-806）资助项目.

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Recent Progress in the Synthesis of N-Substituted-1,2,3-triazoles

  • Liu Qishun ,
  • Lü Yufen ,
  • Bao Pengli ,
  • Yue Huilan ,
  • Wei Wei
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  • a School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong 273165;
    b Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008

Received date: 2020-08-24

  Revised date: 2020-09-28

  Online published: 2020-10-15

Supported by

Project supported by the Youth Innovation and Technology Project of Shandong Province (No. 2019KJC021), the Natural Science Foundation of Shandong Province (No. ZR2018MB009) and the International Cooperation Project of Qinghai Province (No. 2018-HZ-806).

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摘要

N-取代-1，2，3-三氮唑是一类重要的含氮杂环化合物，在药物化学、合成化学及材料等领域都具有广泛的应用价值.因此，N-取代-1，2，3-三氮唑的构建方法备受人们的关注.归纳总结了近年来N-取代-1，2，3-三氮唑的合成研究进展，主要介绍了以叠氮化合物、腙、TsNHNH2和重氮为氮源以及NH-1，2，3-三氮唑为前体合成N-取代-1，2，3-三氮唑化合物的合成路线及其反应机理，并对该领域未来的发展进行了展望.

关键词： N-取代-1,2,3-三氮唑; 叠氮化合物; 腙; TsNHNH2; 重氮; NH-1,2,3-三氮唑

本文引用格式

刘启顺 , 吕玉芬 , 鲍鹏丽 , 岳会兰 , 魏伟 . N-取代-1,2,3-三氮唑化合物的合成研究进展[J]. 有机化学, 2020 , 40(12) : 4015 -4030 . DOI: 10.6023/cjoc202008042

Abstract

N-Substituted-1,2,3-triazoles are an important class of nitrogen-containing hetrocyclic compounds, which exhibited wide applications in various fields such as medicinal chemistry, synthetic chemistry and materials. Therefore, their synthetic methods have attracted great attention of chemists. Herein, the recent research progress in the synthesis of N-substituted-1,2,3-triazoles is summarized. The synthetic routes and reaction mechanisms from raw materials such as azide compounds, diazo compounds, TsNHNH2, hydrazones and NH-1,2,3-triazoles are introduced and reviewed, respectively. Finally, the future development of this field is also prospected.

Key words： N-substituted-1,2,3-triazole; azide compound; hydrazone; TsNHNH2; diazo compound; NH-1,2,3-triazole

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