以氰甲基亚磷酸酯为含膦试剂的铜催化膦酰化异喹啉酮类化合物的高效合成
收稿日期: 2020-08-25
修回日期: 2020-10-18
网络出版日期: 2020-10-22
基金资助
山东省自然科学基金(ZR2016JL012); 青岛科技大学高科技人才资助项目.
Efficient Copper-Catalyzed Domino Synthesis of Phosphonated Isoquinolin-1(2H)-ones Using Cyanomethylphosphonates as Building Blocks
Received date: 2020-08-25
Revised date: 2020-10-18
Online published: 2020-10-22
Supported by
the Natural Science Foundation of Shandong Province(ZR2016JL012); the Scientific Research Foundation of Qingdao University of Science and Technology.()
赵苏艳 , 宫雪芹 , 甘子玉 , 颜秋莉 , 刘学良 , 杨道山 . 以氰甲基亚磷酸酯为含膦试剂的铜催化膦酰化异喹啉酮类化合物的高效合成[J]. 有机化学, 2021 , 41(1) : 258 -266 . DOI: 10.6023/cjoc202008045
An efficient and convenient copper-catalyzed cascade synthesis of C-4 phosphonated isoquinolin-1(2 H)-ones has been initially proposed. This is the first example for the construction of phosphine-containing heterocycles through copper-catalyzed Ullmann-type coupling reactions using cyanomethylphosphonates as the building blocks, and it will broaden the strategies of organophosphorus synthesis in the field of organic and pharmaceutical chemistry.
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