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2021 , Vol. 41 >Issue 4: 1527 - 1542

DOI: https://doi.org/10.6023/cjoc202007034

综述与进展

靛红在苯并氮杂环类化合物的合成应用进展

  • 贾丰成 ,
  • 罗娜 ,
  • 徐程 ,
  • 吴安心
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  • a 武汉工程大学化学与环境工程学院 武汉 430205
    b 湖北师范大学化学化工学院 黄石 435002
    c 华中师范大学化学学院 武汉 430079

收稿日期: 2020-07-12

  修回日期: 2020-10-01

  网络出版日期: 2020-10-28

基金资助

国家自然科学基金(21901193); 湖北省自然科学基金(2018CFB149); 湖北省教育厅科学研究计划中青年人才(Q20181509); 武汉工程大学科学研究基金(K201834)

收起

Recent Advances in the Synthesis of Benzoheterocyclic Compounds Involving Isatins

  • Fengcheng Jia ,
  • Na Luo ,
  • Cheng Xu ,
  • Anxin Wu
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  • a School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073
    b Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, Hubei Normal University, Huangshi 435002
    c Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2020-07-12

  Revised date: 2020-10-01

  Online published: 2020-10-28

Supported by

National Natural Science Foundation of China(21901193); Natural Science Foundation of Hubei Province(2018CFB149); Young and Middle-Aged Talent Program of Hubei Provincial Department of Education(Q20181509); Science Foundation of Wuhan Institute of Technology(K201834)

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摘要

靛红是一种吲哚系天然小分子化合物, 由于其结构独特、廉价易得, 利用靛红作为起始原料来构建结构复杂多样的杂环化合物一直是有机合成领域的研究热点. 由于靛红具有丰富的反应位点, 在转化为类似的“近亲”杂环方面具有显著的步骤优势. 近年来基于靛红的串联反应构建杂环化合物方面研究取得了诸多进展. 根据合成杂环种类的不同, 对靛红参与的串联反应合成苯并杂环化合物的研究进展进行了简要论述.

关键词： 靛红; 串联反应; 苯并杂环化合物; 反应机理

本文引用格式

贾丰成 , 罗娜 , 徐程 , 吴安心 . 靛红在苯并氮杂环类化合物的合成应用进展[J]. 有机化学, 2021 , 41(4) : 1527 -1542 . DOI: 10.6023/cjoc202007034

Abstract

Isatin is a natural small molecule compound of the indole class. Due to its unique structure, low cost and easy availability, the use of isatin as a starting material to construct complex and diverse heterocyclic compounds has been a research hotspot in the field of organic synthesis. Since isatin possess rich reaction sites, it has a significant step advantage in converting it into similar heterocycles. In recent years, the great progress has been made in the construction of heterocyclic compounds based on domino reactions involving isatins. According to the different types of heterocycles, the research progress in the synthesis of benzoheterocyclic compounds by the domino reactions related to isatins is briefly discussed.

Key words： isatins; domino reactions; benzoheterocyclic compounds; reaction mechanism

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