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2021 , Vol. 41 >Issue 3: 1246 - 1250

DOI: https://doi.org/10.6023/cjoc202008002

研究简报

长序三宝木枝叶中一个新的异戊烯基异黄酮类化合物

  • 付艳辉 ,
  • 谢玉桐 ,
  • 马箐伟 ,
  • 蒋波 ,
  • 谢澜 ,
  • 乔泽华 ,
  • 刘艳萍
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  • a 海南师范大学 热带药用资源化学教育部重点实验室 海口 571127
    b 海南师范大学 南药资源产业化关键技术研究海南省工程研究中心 海口 571127
    c 海南师范大学 南药资源产业化关键技术研究海口市重点实验室 海口 571127
    d 中国药科大学 天然药物活性组分与药效国家重点实验室 南京 210009

收稿日期: 2020-08-04

  修回日期: 2020-09-13

  网络出版日期: 2020-11-04

基金资助

海南省重点研发计划(ZDYF2019049); 海南省自然科学基金(2019RC198); 国家自然科学基金(21662011); 国家自然科学基金(31660097); 国家自然科学基金(21967008); 国家自然科学基金(32070390); 国家自然科学基金(22067005); 海口市重点研发计划(2017050); 海口市重点研发计划(20020056)

收起

A New Prenylated Isoflavone from the Stems and Leaves of Trigonostemon howii

  • Yanhui Fu ,
  • Yutong Xie ,
  • Qingwei Ma ,
  • Bo Jiang ,
  • Lan Xie ,
  • Zehua Qiao ,
  • Yanping Liu
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571127
    b Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan province,Hainan Normal University, Haikou 571127
    c Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571127
    d State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009
* Corresponding author. E-mail:

Received date: 2020-08-04

  Revised date: 2020-09-13

  Online published: 2020-11-04

Supported by

Key Research and Development Project of Hainan Province(ZDYF2019049); Natural Science Foundation of Hainan Province(2019RC198); National Natural Science Foundation of China(21662011); National Natural Science Foundation of China(31660097); National Natural Science Foundation of China(21967008); National Natural Science Foundation of China(32070390); National Natural Science Foundation of China(22067005); Key Research and Development Project of Haikou City(2017050); Key Research and Development Project of Haikou City(20020056)

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摘要

综合运用多种现代色谱分离技术对大戟科三宝木属植物长序三宝木Trigonostemon howii枝叶中的化学成分进行了系统研究, 从其枝叶的90%乙醇提取物中分离得到了8个异戊烯基异黄酮类化合物. 采用多种现代波谱鉴定技术确定了这些化合物的化学结构. 其中化合物1为一个新的异戊烯基异黄酮类化合物, 化合物2~8为首次从三宝木属植物中分离得到的化合物. 化合物1~8的体外抗肿瘤活性评价结果表明, 它们对5种肿瘤细胞株(HL-60、A549、SMMC-7721、MCF-7和SW480)均显示出了较为明显的体外生长抑制活性, 抗肿瘤活性与抗肿瘤阳性对照药阿霉素的抗肿瘤活性相当.

关键词： 三宝木属; 长序三宝木; 异戊烯基异黄酮; 抗肿瘤活性

本文引用格式

付艳辉 , 谢玉桐 , 马箐伟 , 蒋波 , 谢澜 , 乔泽华 , 刘艳萍 . 长序三宝木枝叶中一个新的异戊烯基异黄酮类化合物[J]. 有机化学, 2021 , 41(3) : 1246 -1250 . DOI: 10.6023/cjoc202008002

Abstract

A new prenylated isoflavone, trigohowine (1), together with seven known isoflavones, was isolated from the stems and leaves of Trigonostemon howii. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The antitumor activities of compounds 1~8were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). The research results showed that compounds 1~8 exhibited obvious inhibitory effects with IC50 values comparable to those of doxorubicin.

Key words： Trigonostemon; Trigonostemon howii; prenylated isoflavone; antitumor activities

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