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2021 , Vol. 41 >Issue 5: 2127 - 2133

DOI: https://doi.org/10.6023/cjoc202008051

研究简报

酒石酸催化四组分反应合成双螺环四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物

  • 许招会 ,
  • 叶华涛 ,
  • 张文峰 ,
  • 肖强
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  • a 江西师范大学化学化工学院 南昌 330022
    b 江西省人民医院骨科 南昌 330006

收稿日期: 2020-08-27

  修回日期: 2020-12-13

  网络出版日期: 2020-12-31

基金资助

江西省研究生创新基金(YC2015-B023); 江西省教育厅科技计划研究项目(GJJ170170); 江西省教育厅科技计划研究项目(GJJ180892); 江西师范大学博士科研启动基金(JXSDBY2020-B012)

收起

A Four-Component Reaction for the Synthesis of Dispirotetrahydro-quinoline-bis(1,3-dioxane-4,6-dione) Derivatives Catalyzed by Tartaric Acid

  • Zhaohui Xu ,
  • Huatao Ye ,
  • Wenfeng Zhang ,
  • Qiang Xiao
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  • a Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022
    b Department of Orthopedics, Jiangxi Province People?s Hospital, Nanchang 330006
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2020-08-27

  Revised date: 2020-12-13

  Online published: 2020-12-31

Supported by

Graduate Innovation Foundation of Jiangxi Province(YC2015-B023); Science and Technology Research Project of Jiangxi Provincial Education Department(GJJ170170); Science and Technology Research Project of Jiangxi Provincial Education Department(GJJ180892); Jiangxi Normal University Doctoral Research Initiation Fund Project(JXSDBY2020-B012)

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摘要

在酒石酸催化作用下, 以1,3-二噁烷-4,6-二酮、芳香醛、芳香胺和丙酮为原料, 通过四组分反应有效地合成了11种双螺环四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物. 该方法具有产物收率高、适用范围较广、反应温和、操作简单及环境友好等优点, 同时对反应机理进行了推测.

关键词： 酒石酸; 四组分反应; 1,3-二噁烷-4,6-二酮; 四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物

本文引用格式

许招会 , 叶华涛 , 张文峰 , 肖强 . 酒石酸催化四组分反应合成双螺环四氢喹啉双(1,3-二噁烷-4,6-二酮)衍生物[J]. 有机化学, 2021 , 41(5) : 2127 -2133 . DOI: 10.6023/cjoc202008051

Abstract

Eleven dispirotetrahydroquinoline-bis(1,3-dioxane-4,6-dione) derivatives were synthesized by a four-component reaction of 1,3-dioxane-4,6-dione, aromatic aldehydes, arylamines and acetone in the presence of tartaric acid. This method can provide the advantages of high yields, broader substrate scope, mild conditions, simple operation and environmental friendliness. Additionally, the reaction mechanism was also speculated.

Key words： tartaric acid; four-component reaction; 1,3-dioxane-4,6-dione; dispirotetrahydroquinoline-bis(1,3-dioxane-4,6- dione) derivative

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