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2021 , Vol. 41 >Issue 5: 2038 - 2044

DOI: https://doi.org/10.6023/cjoc202011014

研究论文

乙酸铵催化的酚与多聚甲醛的甲酰化反应研究

  • 李倩 ,
  • 杨丽 ,
  • 刘伟 ,
  • 王天昀 ,
  • 朱月杰 ,
  • 杜正银
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  • 1 西北师范大学化学化工学院 兰州 730070

收稿日期: 2020-11-09

  修回日期: 2020-12-26

  网络出版日期: 2021-02-07

基金资助

国家自然科学基金(21262028); 国家自然科学基金(21762039); 甘肃省自然科学基金(20JR5RA521)

收起

Formylation of Phenols and Paraformaldehyde Catalyzed by Ammonium Acetate

  • Qian Li ,
  • Li Yang ,
  • Wei Liu ,
  • Tianyun Wang ,
  • Yuejie Zhu ,
  • Zhengyin Du
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  • 1 College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
* Corresponding author. E-mail:

Received date: 2020-11-09

  Revised date: 2020-12-26

  Online published: 2021-02-07

Supported by

National Natural Science Foundation of China(21262028); National Natural Science Foundation of China(21762039); Natural Science Foundation of Gansu Province(20JR5RA521)

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摘要

在乙酸铵作为催化剂的条件下, 萘酚和多聚甲醛在醋酸溶液中反应, 成功合成了一系列羟基萘甲醛, 收率最高达86%. 将该方法应用于苯酚及取代苯酚的甲酰化反应, 以42%~58%的中等收率得到水杨醛类化合物. 根据反应结果提出了可能的作用机理. 该方法不使用任何金属试剂, 具有反应条件温和、操作简单及成本低廉的特点.

关键词： 萘酚; 苯酚; 多聚甲醛; 甲酰化反应; 绿色合成

本文引用格式

李倩 , 杨丽 , 刘伟 , 王天昀 , 朱月杰 , 杜正银 . 乙酸铵催化的酚与多聚甲醛的甲酰化反应研究[J]. 有机化学, 2021 , 41(5) : 2038 -2044 . DOI: 10.6023/cjoc202011014

Abstract

The reaction of naphthol and paraformaldehyde in acetic acid solution with ammonium acetate as a catalyst resulted in the synthesis of a series of hydroxynaphthalenes in yields of up to 86%. Several phenols were also transformed into the corresponding salicylaldehydes under the same reaction conditions in moderate yields of 42%~58%. A rational mechanism was also proposed based on the facts of experimental observations. This metal-free process has the advantages of mild reaction conditions, simple operation and low cost.

Key words： naphthol; phenol; paraformaldehyde; formylation reaction; green synthesis

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