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2021 , Vol. 41 >Issue 4: 1722 - 1727

DOI: https://doi.org/10.6023/cjoc202012017

研究简报

新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物的设计合成以及生物活性研究

  • 谢伟彬 ,
  • 李焕功 ,
  • 孟祥德 ,
  • 李正名 ,
  • 周莎
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  • 1 南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071

收稿日期: 2020-12-09

  修回日期: 2020-12-31

  网络出版日期: 2021-02-07

基金资助

国家重点研究开发计划(2018YFD0200100); 国家自然科学基金(21602118)

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Design, Synthesis and Biological Activity Study of Novel N-Phenylpyrazole Anthranilic Diamides Containing Heptafluoroisopropyl Moieties

  • Weibin Xie ,
  • Huangong Li ,
  • Xiangde Meng ,
  • Zhengming Li ,
  • Sha Zhou
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  • 1 State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 30071
* Corresponding author. E-mail: ;
E-mail:

Received date: 2020-12-09

  Revised date: 2020-12-31

  Online published: 2021-02-07

Supported by

National Key Research and Development Plan(2018YFD0200100); National Natural Science Foundation of China(21602118)

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摘要

为了开发出高效、低毒性的新型绿色农药, 引入七氟异丙基, 设计合成了新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物, 其结构经过NMR, HRMS分析确认. 初步的生物活性测定表明, 大部分化合物含有较好的杀虫活性, 其中化合物Ic在2.5 mg/L时抑制率为20%. 本研究结果为后期的农药创制工作奠定了一定的基础.

关键词： 七氟异丙基; 邻甲酰氨基苯甲酰胺; 合成; 杀虫活性

本文引用格式

谢伟彬 , 李焕功 , 孟祥德 , 李正名 , 周莎 . 新型含N-七氟异丙基苯基吡唑的邻甲酰氨基苯甲酰胺类化合物的设计合成以及生物活性研究[J]. 有机化学, 2021 , 41(4) : 1722 -1727 . DOI: 10.6023/cjoc202012017

Abstract

In order to develop new green pesticides with high efficiency and low toxicity, N-phenylpyrazole anthranilic diamides containing heptafluoroisopropyl moieties were designed, synthesized and evaluated for their insecticidal activity against Oriental armyworm. Their structures were confirmed by NMR and HRMS analysis. Preliminary biological activity showed that most of the compounds exhibited good insecticidal activity. In particular, compound Ic againstOriental armywormwas 20% at 2.5 mg/L. This result laid a certain foundation for the innovation of ryanodine receptor insecticides in the future.

Key words： heptafluoroisopropyl; anthranilic diamide; synthesis; insecticidal activity

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