HBr催化α-溴代甲基酮类化合物的全脱溴反应研究
收稿日期: 2020-10-06
修回日期: 2020-12-14
网络出版日期: 2021-02-22
基金资助
新疆维吾尔自治区2017年自治区“天山青年计划”(2017Q026)
Study on the Debromination of α-Bromomethyl Ketones Catalyzed by HBr
Received date: 2020-10-06
Revised date: 2020-12-14
Online published: 2021-02-22
Supported by
Xinjiang Uygur Autonomous Region 2017 Tianshan Youth Program(2017Q026)
报道了HBr催化下以水为氢源的α-溴代甲基酮类化合物的脱溴化反应. 以α-溴代甲基酮类化合物为原料, 四氢呋喃为溶剂, α-溴代甲基酮与质量分数5%的氢溴酸的物质的量比为1.0:0.2时, 在180 ℃下反应5~14 h, 分离产率高达94% [高效液相(HPLC)产率96%]的脱溴产物. 该方法无金属催化剂参与, 催化剂价格低廉, 所有产物均经1H NMR和13C NMR结构确证.
关键词： α-溴代甲基酮类化合物; HBr; 脱溴
郑梦霞 , 曾竟 , 买里克扎提?买合木提 , 阿布都热西提?阿布力克木 . HBr催化α-溴代甲基酮类化合物的全脱溴反应研究[J]. 有机化学, 2021 , 41(5) : 2121 -2126 . DOI: 10.6023/cjoc202010006
The debromination reaction of α-bromomethylketone compounds was achieved by using water as the hydrogen source under the catalysis of HBr. Using α-bromomethylketones as raw materials, tetrahydrofuran as solvent, when the molar ratio of α-bromomethylketone to 5% mass fraction hydrobromic acid was 1.0:0.2, the debrominated product could be obtained with a isolated yield of 94% [high performance liquid chromatography (HPLC) yield 96%] by reacting at 180 ℃ for 5~14 h. All products were confirmed by1H NMR and 13C NMR spectra.
Key words： α-bromomethylketone; HBr; debromination
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