SIOC English
有机化学
高级检索

有机化学 >

2021 , Vol. 41 >Issue 6: 2511 - 2514

DOI: https://doi.org/10.6023/cjoc202012045

研究简报

五倍子中一个新的甘遂烷型三萜类化合物

  • 李钰婷 ,
  • 仝雪利 ,
  • 田立文
展开
  • 南方医科大学药学院 广州 510515

收稿日期: 2020-12-27

  修回日期: 2021-01-28

  网络出版日期: 2021-02-26

基金资助

国家自然科学基金(81703381)

收起

A New Tirucallane Triterpenoid from Galla chinensis

  • Yuting Li ,
  • Xueli Tong ,
  • Liwen Tian
Expand
  • School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515
*Corresponding author.E-mail:

Received date: 2020-12-27

  Revised date: 2021-01-28

  Online published: 2021-02-26

Supported by

National Natural Science Foundation of China(81703381)

Fold

摘要

从五倍子的乙酸乙酯提取物中分离得到一个新的甘遂烷型三萜和五个已知的甘遂烷型三萜. 化合物的结构通过多种波谱分析技术得到鉴定. 这是首次从五倍子中分离得到三萜类化合物. 其中, 乳香二烯酮酸(3)、异乳酸二烯酮(4)和masticadienolic acid (5)在浓度为1.6 μmol•L –1时显示出神经保护活性, 该研究为发现神经保护药物提供了一个结构模板.

关键词： 五倍子; 甘遂烷型三萜; 神经保护活性

本文引用格式

李钰婷 , 仝雪利 , 田立文 . 五倍子中一个新的甘遂烷型三萜类化合物[J]. 有机化学, 2021 , 41(6) : 2511 -2514 . DOI: 10.6023/cjoc202012045

Abstract

A new tirucallane triterpenoid was isolated from the ethyl acetate extract of Galla chinensis, along with five known tirucallane triterpenoids. Their structures were elucidated by extensive spectrosopic data analysis. It is the first time to report triterpenoids from G. chinensis. Masticadienonic acid (3), isomasticadienonic acid (4) and masticadienolic acid (5) showed neuroprotective activity at a concentration of 1.6 μmol•L –1. This study provides a structure template for neuroprotection agent discovery.

Key words： Galla chinensis; tirucallane triterpenoid; neuroprotective activity

参考文献

[1]
Chinese Pharmacopoeia Commission, Chinese Pharmacopoeia, Vol. 1, China Medical Science Press, Beijing, 2016, pp.67~68(in Chinese).
[1]
(中华人民共和国药典委员会, 中国药典,第一版, 中国医药科技出版社, 北京, 2016, pp.67~68.)
[2]
Li, Y.; Wu, X.; Xing, X. Shandong J. Tradit. Chin. Med. 2020, 39,509(in Chinese).
[2]
(李杨, 吴侠, 邢效銘, 山东中医杂志, 2020, 39,509.)
[3]
Djakpo, O.; Yao, W. Phytother. Res. 2010, 24,1739.
[4]
Ahn, Y. J.; Lee, H. S.; Oh, H. S.; Kim, H. T.; Lee, Y. H. Pestic. Biochem. Physiol. 2005, 81,105.
[5]
An, R. B.; Oh, H.; Kim, Y. C. Biol. Pharm. Bull. 2005, 28,2155.
[6]
Park, E. J.; Zhen, Z. Y.; An, R. B.; Kim, Y. C.; Sohn, D. H. Planta Med. 2008, 74,1380.
[7]
Lee, J. J.; Bae, J. H.; Kim, D. H.; Lim, J. J.; Kim, D. G.; Lee, H. J.; Min, W.; Rhee, M. H.; Chang, H. H.; Park, H.; Kim, S. J. Ethnopharmacol. 2011, 138,602.
[8]
Chen, J. C.; Ho, T. Y.; Chang, Y. S.; Wu, S. L.; Hsiang, C. Y. J. Ethnopharmacol. 2006, 103,385.
[9]
Tian, F.; Li, B.; Ji, B.; Yang, J.; Zhang, G.; Chen, Y.; Luo, Y. Food Chem. 2009, 113,173.
[10]
Kwon, O. J.; Bae, J. S.; Lee, H. Y.; Hwang, J. Y.; Lee, E. W.; Ito, H.; Kim, T. H. Molecules 2013, 18,10629.
[11]
Ihn, H. J.; Kim, T. H.; Kim, K.; Kim, G. Y.; Jeon, Y. J.; Choi, Y. H.; Bae, J. S.; Kim, J. E.; Park, E. K. BMB Rep. 2019, 52,409.
[12]
Tong, X. L.; Wang, H. T.; Xu, J. P.; Tian, L. W. Nat. Prod. Res. 2020, 34,204.
[13]
Deng, J. Z.; Starck, S. R.; Sun, D. A.; Sabat, M.; Hecht, S. M. J. Nat. Prod. 2000, 63,1356.
[14]
Camacho, M. R.; Mata, R.; Castaneda, P.; Kirby, G. C.; Warhurst, D. C.; Croft, S. L.; Phillipson, J. D. Planta Med. 2000, 66,463.
[15]
Dharmayani, N. K. T.; Juliawaty, L. D.; Syah, Y. M. Nat. Prod. Commun. 2016, 11,1081.
[16]
Mulholland, D. A.; Nair, J. J. Phytochemistry 1994, 37,1409.
[17]
Pozzo-Balbi, T.; Nobile, L.; Scapini, G.; Cini, M. Phytochemistry 1978, 17,2107.
Options
文章导航

/

〈 〉